介入治疗中药物涂层球囊长度与冠心病患者临床结局的关系  

Relationship Between the Length of Drug-Coated Balloon in Interventional Therapy and Clinical Outcome of Coronary Heart Disease

作　　者：杨广兴 杨利果 弓向荣 YANG Guangxing;YANG Liguo;GONG Xiangrong(Department of Cardiology,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China;Department of Endocrinology,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China)

机构地区：[1]郑州大学第一附属医院心血管内科,河南郑州450052 [2]郑州大学第一附属医院内分泌科,河南郑州450052

出　　处：《河南医学研究》2021年第11期1952-1956,共5页Henan Medical Research

摘　　要：目的探讨药物涂层球囊(DCB)长度与冠心病患者临床结局的关系。方法本研究为回顾性研究,选取2017年6月至2018年6月在郑州大学第一附属医院接受DCB治疗的249例冠心病患者,依据置入的DCB长度分为15 mm组(155例)和30 mm组(94例)。统计两组患者DCB术后2 a内主要不良心血管事件(MACE,由心源性死亡、心肌梗死及靶病变血运重建构成的复合指标)发生情况,单因素生存分析采用Kaplan-Meier法和log-rank检验。结果与15 mm组比较,30 mm组DCB术后夹层发生率更高(P<0.05),2 a的随访中两组MACE发生率差异无统计学意义(10.97%比14.89%,P>0.05),两组患者生存曲线差异无统计学意义(P>0.05)。结论DCB的长度与临床结局无关。Objective To investigate the relationship between clinical outcomes of coronary heart disease and length of the drug-coated balloon(DCB).Methods A total of 249 patients who were treated with DCB from June 2017 to November 2019 were retrospectively enrolled in this study.According to the inserted DCB length,they were divided into 15 mm group(155 cases)and 30 mm group(94 cases).The occurrence of major adverse cardiovascular events(MACE,a composite index composed of cardiac death,myocardial infarction and revascularization of target lesions)within 2 years after DCB was followed up in the two groups of patients.Kaplan-Meier method and log-rank test were used of univariate survival analysis.Results The 30 mm group had a higher incidence of post-DCB dissection compared with 15 mm group(P<0.05).There was no difference between 30 mm group and 15 mm group in the incidence of MACE during the 2-year follow-up(10.97%versus 14.89%,P>0.05),and there was no difference between 30 mm group and 15 mm group in survival curve(P>0.05).Conclusion The length of DCB was not associated with clinical outcomes.

关 键 词：冠状动脉粥样硬化性疾病 介入治疗 药物涂层球囊 主要不良心血管事件 

分 类 号：R541.4[医药卫生—心血管疾病]