蛋白聚糖调控间充质干细胞成骨分化的研究进展  

Role of proteoglycans in regulating the osteogenic differentiation of mesenchymal stem cells:A review

作　　者：吴靖漪 陈嘉文 孙天语 刘鹏[5] 吴补领[3,6] WU Jingyi;CHEN Jiawen;SUN Tianyu;LIU Peng;WU Buling(Center for Implant Dentistry,Stomatological Hospital,Southern Medical University,Guangzhou 510280,China;不详)

机构地区：[1]南方医科大学口腔医院种植中心,广州510280 [2]南方医科大学南方医院口腔科,广州510515 [3]南方医科大学口腔医学院,广州510515 [4]南方医科大学口腔医院牙周科,广州510280 [5]南方医科大学珠江医院口腔科,广州510282 [6]南方医科大学深圳口腔医院(坪山),广东深圳518118

出　　处：《实用医学杂志》2021年第9期1217-1221,共5页The Journal of Practical Medicine

基　　金：国家自然科学基金(编号:81900956);南方医科大学口腔医院博士后专项基金(编号:PY2018025);南方医科大学科研启动项目(编号:QD2018N030)。

摘　　要：创伤和肿瘤导致的大面积骨缺损是临床上亟待解决的难题,利用间充质干细胞(mesenchymalstemcells,MSCs)介导骨组织再生具有巨大的应用前景。探究干细胞在骨组织微环境中的转归及其与微环境之间的相互作用对其临床转化至关重要,然而目前相关研究仍处于探索阶段。蛋白聚糖作为MSCs微环境重要的组成部分及调节分子,广泛参与了MSCs自我更新和成骨分化的动态平衡的调节过程。多项研究证实蛋白聚糖是骨缺损再生修复中的重要调控因子,深入揭示蛋白聚糖在MSCs成骨向分化中所起的调控作用,并逐渐将其局部应用在骨修复材料中已成为近年来国内外的研究热点。本文将重点就蛋白聚糖在调控不同间充质干细胞成骨分化中的作用、潜在机制及其临床应用进行综述。Bone defect arising secondary to trauma and cancer remains a major challenge for surgeons.Currently,mesenchymal stem cells are showed to be potential in its role in bone regeneration at clinical practice.The critical researches on the fate of stem cells in bone microenvironment as well as the interaction between them are still in the exploratory stage,which limits the development of stem cell⁃based therapies.Proteoglycans,the essential components and regulatory factors of the mesenchymal stem cell microenvironment,involve in the regulation of stem cell homestasis and osteogenic differentiation.Growing evidence has demonstrated that proteoglycans play a key role in regulating the regeneration of bone defects.Therefore,the domestic and foreign researches are now focusing on further revealing the mechanisms of proteoglycans in regulating the osteogenic differentiation of mesen⁃chymal stem cells,and gradually promoting its topical application in the bone reconstruction field.This article has reviewed and summarized the latest research on the role of proteoglycans in regulating the osteogenic differentiation of different mesenchymal stem cells,its underlying mechanism and its current clinical application.

关 键 词：蛋白聚糖 糖胺聚糖链 间充质干细胞 成骨分化 

分 类 号：R318[医药卫生—生物医学工程]