大黄的作用机制及临床的研究现状  

Mechanism of Rhubarb Action and Present Status of Clinical Research

作　　者：杜兆远 刘永武[1] 张娜[1] 赵良友[1] 翟旭楠 范卓文[1] DU Zhao-yuan;LIU Yong-wu;ZHANG Na(Heilongjiang University of Traditional Chinese Medicine,Harbin,Heilongjiang,150040,China)

机构地区：[1]黑龙江中医药大学,黑龙江哈尔滨150040

出　　处：《黑龙江医学》2021年第9期1001-1004,共4页Heilongjiang Medical Journal

基　　金：黑龙江中医药大学博士创新科研基金项目(051761)。

摘　　要：最近研究表明,大黄除了传统疗效外,还具有双向调节作用以及在抗癌方面有着巨大的潜能。大黄的作用机制与机体的炎症反应、抗氧化、细胞凋亡和自噬作用有关,并发现大黄对肝肾等重要器官具有一定的毒副作用。本文主要从大黄的作用机制和临床应用这两个方面对近5年的文献进行总结和讨论。Recent studies have shown that rhubarb,in addition to the traditional efficacy,has a bidirectional regulatory effect and has great potential in anticancer.The mechanism of rhubarb is related to inflammation,antioxidation,apoptosis and autophagy and it is found that rhubarb has some toxic side effects on important organs such as liver and kidney.This paper summarizes and discusses the literature of the last 5 years from the two aspects of the mechanism and clinical application of rhubarb.

关 键 词：大黄 炎症反应 抗氧化 细胞凋亡和自噬 

分 类 号：R28[医药卫生—中药学]