α,γ-二羰基丁酸酯的不对称氢化反应研究  

Asymmetric hydrogenation ofα,γ-dioxo-butyric acid esters

作　　者：王巧峰 陈雷[1] WANG Qiao-feng;CHEN Lei(Medical School,Xi’an Peihua University,Xi’an,710199,China)

机构地区：[1]西安培华学院医学院,陕西西安710199

出　　处：《化学研究与应用》2021年第5期957-960,共4页Chemical Research and Application

基　　金：陕西省自然科学基础研究计划重点项目(2020JZ-26)资助。

摘　　要：进行了基于二茂铁结构的手性金属配合物催化剂催化4-芳基-2,4-二羰基丁酸酯的不对称氢化反应探索。考察了手性配体结构、反应溶剂、反应温度和H_(2)压力对反应的影响。在最佳条件下进行了6种4-芳基-2,4-二羰基丁酸酯的AH反应,并以高达88%的分离产率和69%ee获得相应反应产物。The asymmetric hydrogenation(AH)of a series ofγ-aryl-α,γ-dioxo-butyric acid esters had been conducted successfully in the presence of chiral ferrocene-based-ligand-Ru complex.The effect of ligands,solvent,temperature and H_(2) pressure on the reaction was investigated.Under the optimized reaction conditions,six substrates were enantioselectively reduced smoothly in 88%separation yield with up to 69%ee.

关 键 词：不对称氢化反应 α γ-二羰基丁酸脂 二茂铁配体 

分 类 号：O626.23[理学—有机化学]