2-(芳氧甲基)喹啉-3,4-二羧酸的“一锅法”合成  

One-pot synthesis of 2-(aroxymethyl)quinoline-3,4-dicarboxylic acids

作　　者：张红[1] 刘佳 黄文远 李阳[1] 蔡东 ZHANG Hong;LIU Jia;HUANG Wen-yuan;LI Yang;CAI Dong(College of Chemistry and Materials Engineering,Bohai University,Jinzhou 121000,China;Chaoyang Inspection and Testing Certification Center,Chaoyang 122000,China;Fuxin Institute For Drug Control,Fuxin 123000,China;College of Public Basic Sciences,Jinzhou Medical University,Jinzhou 121000,China)

机构地区：[1]渤海大学化学与材料工程学院,辽宁锦州121000 [2]朝阳市检验检测认证中心,辽宁朝阳122000 [3]阜新市药品检验所,辽宁阜新123000 [4]锦州医科大学公共基础学院,辽宁锦州121000

出　　处：《化学研究与应用》2021年第5期975-984,共10页Chemical Research and Application

基　　金：辽宁省教育厅项目(LQ2019006)资助;辽宁省科技厅博士启动项目(2019-BS-004)资助。

摘　　要：本文设计了以实验室自制的2-(溴甲基)喹啉-3,4-二甲酸乙酯为起始化合物,与各种取代的酚经一锅连续的Williamson醚合成和酯水解反应,简便而有效地合成了一系列结构新颖的2-(芳氧甲基)喹啉-3,4-二羧酸,其结构通过波谱数据和元素分析得以证实。该合成方法具有实验简单、所用试剂便宜和收率高等优点,这将有助于该方法的应用。In this work,a simple and convenient synthesis of a series of structurally novel 2-(aroxymethyl)quinoline-3,4-dicarboxylic acids had been achieved with good yields for the first time,involving one-pot sequential Williamson reaction between the newly synthesized diethyl 2-(bromomethyl)quinoline-3,4-dicarboxylate and various substituted phenols followed by subsequent ester hydrolysis reaction.The structures of these title compounds had been established on the basis of spectral data and elemental analyses.Our synthetic strategy featured experimental simplicity,inexpensive reagents and satisfactory yields,which would contribute to the usefulness of this method.

关 键 词：喹啉 二羧酸 “一锅法”合成 Williamson反应 水解 

分 类 号：O625[理学—有机化学]