O型血孕妇血清中IgG抗A(B)抗体效价与ABO新生儿溶血病的相关性研究  

Study on the correlation between the titer of IgG anti A(B)antibody in the serum of pregnant women with type O blood and ABO hemolytic disease of the newborn

作　　者：刘莹[1] 杨珍珍[1] 刘小艳[1] 安莹花[1] 梁会娟[1] 杨雅梅[2] LIU Ying;YANG Zhenzhen;LIU Xiaoyan;AN Yinghua;LIANG Huijuan;YANG Yamei(Blood Transfusion Department,Baoji Maternal and Child Health Care Hospital,Baoji 721000;Clinical Laboratory Department,Baoji City People's Hospital,Baoji 721000,China)

机构地区：[1]宝鸡市妇幼保健院输血科,陕西宝鸡721000 [2]宝鸡市人民医院检验科,陕西宝鸡721000

出　　处：《临床医学研究与实践》2021年第15期7-9,共3页Clinical Research and Practice

基　　金：宝鸡市科技计划项目(No.16SFGG3-16)。

摘　　要：目的探讨O型血孕妇血清中IgG抗A(B)抗体效价与ABO新生儿溶血病(HDN)的相关性。方法选取在我院进行产前检查、分娩的328例O型血产妇(其丈夫非O型血,夫妻均为RhD阳性)及其分娩的新生儿为研究对象。按照夫妻血型将孕妇分为A-O组(132例)、B-O组(139例)、AB-O组(57例)。自孕20周开始每4周用微柱凝胶法监测孕妇体内血清IgG抗体抗A(B)的效价,采用直接抗球蛋白试验、游离抗体试验和热放散试验判定新生儿发生HDN与否。结果三组O型血孕妇产前血清中IgG抗A(B)抗体效价≤1∶32的占比比较,差异具有统计学意义(P<0.05)。血清IgG抗A(B)抗体效价不同的孕妇所分娩的新生儿ABO-HDN发生率比较,差异具有统计学意义(P<0.05)。孕妇血清IgG抗A(B)抗体效价与新生儿ABO-HDN发生率呈正相关性(r=0.69,P<0.05)。结论O型血孕妇血清中IgG抗A(B)抗体效价与ABO-HDN之间存在正相关性,临床上通过检测孕妇血清中的抗A(B)抗体效价对于HDN的早期发现和预防尤为重要。Objective To investigate the correlation between the titer of IgG anti A(B)antibody in the serum of pregnant women with type O blood and ABO hemolytic disease of the newborn(HDN).Methods A total of 328 pregnant women with type O blood(whose husbands were not O blood type,and both the husband and wife were RhD positive)who underwent prenatal examination and delivery and their newborns in our hospital were selected as the study objects.The pregnant women were divided into A-O group(132 cases),B-O group(139 cases)and AB-O group(57 cases)according to the blood type of husband and wife.The titer of IgG anti A(B)antibody in the serum of pregnant women was monitored by microcolumn gel method every 4 weeks from 20 weeks of gestation,and whether HDN occurred or not in newborns was determined by direct antiglobulin test,free antibody test and heat release test.Results There was significant difference in the proportion of titer of IgG anti A(B)antibody≤1∶32 in serum of pregnant women with type O blood in prenatal among the three groups(P<0.05).There was significant difference in the incidence of ABO-HDN in newborns among pregnant women with different titer of serum IgG anti A(B)antibody(P<0.05).There was a positive correlation between the titer of IgG anti A(B)antibody in the serum of pregnant women and the incidence of ABO-HDN in newborns(r=0.69,P<0.05).Conclusion There was a positive correlation between the titer of IgG anti A(B)antibody in the serum of pregnant women with type O blood and the incidence of ABO-HDN in newborns.It is very important to detect the titer of IgG anti A(B)antibody in the serum of pregnant women for the early detection and prevention of HDN.

关 键 词：O型血 新生儿溶血病 微柱凝胶法 IGG抗体 RhD阳性 

分 类 号：R722.1[医药卫生—儿科]