血小板参数及外周血细胞比值在腹膜透析患者腹主动脉钙化中的预测价值  

Predictive value of platelet parameters and peripheral blood cell ratios for abdominal aortic calcification of peritoneal dialysis patients

作　　者：赵诗竹 曹婧媛[2] 曹裴扬 卢国元[1] Zhao Shi-zhu;Cao Jing-yuan;Cao Pei-yang;Lu Guo-yuan(Department of Nephrology,First Affiliated Hospital,Soochow University,Suzhou 215000,China;Department of Nephrology,Municipal People’s hospital,Taizhou 225300,China)

机构地区：[1]苏州大学附属第一医院肾内科,215000 [2]泰州市人民医院肾内科,225300

出　　处：《临床肾脏病杂志》2021年第5期397-402,共6页Journal Of Clinical Nephrology

摘　　要：目的评估血小板相关参数及外周血细胞比值与腹膜透析(peritoneal dialysis, PD)患者腹主动脉钙化(abdominal aortic calcification, AAC)的关系。方法回顾性分析2019年8月至2020年2月于苏州大学附属第一医院肾内科行腹膜透析充分性评估的PD患者临床及实验室资料,使用腹部多层螺旋CT评估患者的AAC情况,采用二元Logistic回归分析血小板相关参数、外周血细胞比值与AAC的关系。结果共纳入成年PD患者153例,其中AAC组83例,无AAC组70例。相较于无AAC组,AAC组外周血小板分布宽度(platelet distribution width, PDW)更高,淋巴细胞/单核细胞比值(lymphocyte to monocyte ratio, LMR)更低。Logistic回归分析显示,年龄(OR=1.192)、透析龄(OR=1.035)、白蛋白(OR=0.865)、PDW(OR=1.482)、血磷(OR=14.436)、血钙(OR=70.751)与PD患者发生AAC独立相关。结论在血小板参数及外周血细胞比值中,PDW升高与PD患者AAC的发生独立相关,临床可同时结合PD患者年龄、透析龄、血钙、血磷、白蛋白水平综合评估AAC的发生风险。Objective To explore the associations between platelet parameters or peripheral blood cell ratios and abdominal aortic calcification(AAC)in peritoneal dialysis(PD)patients.Methods For this cross-sectional study,153 PD patients undergoing a dialysis adequacy test from August 2019 to February 2020 were recruited.Demographic profiles,laboratory parameters and abdominal computed tomography(CT)scans were analyzed.Results Among them,83(54.24%)patients were divided into AAC group with higher platelet distribution width(PDW)as well as lower lymphocyte/monocyte ratio(LMR).Multivariable Logistic regression revealed that higher age(OR=1.192),longer PD vintage(OR=1.035),greater PDW(OR=1.482),higher calcium(OR=70.751)and higher phosphate(OR=14.436)were associated with higher risks of AAC while higher serum albumin(OR=0.865)denoted a lower probability of AAC.Conclusion Among different platelet parameters and peripheral blood cell ratios,higher PDW is independently associated with AAC in PD patients.Clinically age,PD vintage,serum albumin,calcium and phosphate along with PDW may be combined for evaluating the risks of AAC.

关 键 词：腹膜透析 腹主动脉钙化 血小板分布宽度 淋巴细胞/单核细胞比值 

分 类 号：R692.5[医药卫生—泌尿科学] R543.1[医药卫生—外科学]