影像学评价大鼠胶质瘤及其微环境的研究进展  

Advances in research on imaging evaluations of rat glioma and its microenvironment

作　　者：邓娟 李昇霖 刘显旺 薛彩强 周俊林[1,3] DENG Juan;LI Shenglin;LIU Xianwang;XUE Caiqiang;ZHOU Junlin(Department of Radiology,Lanzhou University Second Hospital,Lanzhou 730030,China;the Second School of Clinical Medicine,Lanzhou University,Lanzhou 730030,China;Key Laboratory of Medical Imaging of Gansu Province,Lanzhou 730030,China)

机构地区：[1]兰州大学第二医院放射科,甘肃兰州730030 [2]兰州大学第二临床医学院,甘肃兰州730030 [3]甘肃省医学影像重点实验室,甘肃兰州730030

出　　处：《中国医学物理学杂志》2021年第5期578-581,共4页Chinese Journal of Medical Physics

基　　金：国家自然科学基金(81772006)。

摘　　要：胶质瘤动物模型的建立对了解肿瘤的发生、发展及转归发挥着不可或缺的作用,而影像学作为一种无创手段,不仅可以对肿瘤进行宏观显像,而且可以对肿瘤微观结构及微环境改变进行定性定量评估。本文就影像学在评估大鼠胶质瘤肿瘤血管生成与抗血管生成、肿瘤乏氧状态、肿瘤微观结构及治疗后改变的研究现状进行综述,并归纳了不同成像方式的参数与肿瘤病理组织之间的相关性,总结了不同成像方式的优势,为影像学在胶质瘤诊治中的应用提供原理支持,同时为临床诊治胶质瘤提供新思路。The establishment of animal model of glioma plays an indispensable role in understanding the occurrence,development and regression of glioma.As a non-invasive method,imaging can be used to not only realize macroscopic tumor imaging,but also qualitatively and quantitatively assess tumor microstructures and microscopic environmental changes.Herein the research status of imaging in evaluating glioma angiogenesis and anti-angiogenesis in rats,tumor hypoxia,tumor microstructure and their changes after treatment is reviewed;and the relationships between the parameters of different imaging modalities and tumor histopathology are analyzed;and finally the advantages of different imaging modalities are summarized.The review provides principle support for the application of imaging in the diagnosis and treatment of glioma,and new ideas for clinical diagnosis and treatment of glioma.

关 键 词：胶质瘤 体层摄影术 磁共振成像 正电子发射断层显像术 综述 

分 类 号：R332[医药卫生—人体生理学] R739.41[医药卫生—基础医学]