间充质干细胞在调节新型冠状病毒肺炎患者免疫功能中的应用  

Application of mesenchymal stem cells in regulating immune function of patients with coronavirus disease-2019

作　　者：卢昆 耿仕涛 夏婧[1] 唐士凯[1] 张玮[1] 吴海鹰[1] 钱传云[1] Lu Kun;Geng Shitao;Xia Jing;Tang Shikai;Zhang Wei;Wu Haiying;Qian Chuanyun(Emergency Department,the First Affiliated Hospital of Kunming Medical University,Kunming 650032,China;NHC Key Laboratory of Drug Addiction Medicine,Kunming Medical University,Kunming 650032,China)

机构地区：[1]昆明医科大学第一附属医院急诊科,650032 [2]昆明医科大学国家卫健委毒品依赖与戒治重点实验室,650032

出　　处：《中华重症医学电子杂志》2021年第1期55-65,共11页Chinese Journal Of Critical Care & Intensive Care Medicine(Electronic Edition)

基　　金：云南省后备人才项目(H-201616);昆明医科大学研究生创新基金项目(2020S165)。

摘　　要：新型冠状病毒肺炎(COVID-19)是一种具有潜在致死性的传染性疾病,严重损害机体免疫系统,会导致免疫细胞过度激活,使炎性细胞因子大量释放,形成细胞因子风暴,从而加剧组织损伤和病情的发展。有效控制炎症因子风暴,已成为治疗COVID-19患者的关键点。间充质干细胞(MSCs)凭借其低免疫原性和对先天性和适应性免疫的调节能力,能够有效控制异常的免疫反应,抑制其对人体多器官造成的损伤。结合COVID-19患者免疫改变的特征和先前的研究,MSCs对COVID-19的治疗可能具有有良好的效果。本文通过分析COVID-19患者先天性和适应性免疫反应的改变,阐明MSCs对免疫的调节作用及机制,以期为COVID-19患者临床免疫治疗提供新的思路和理论基础。Coronavirus disease-2019(COVID-19)is a potentially fatal infectious disease.COVID-19 can seriously damage the immune system,leading to the over-activation of immune cells,so that a large number of inflammatory cytokines are released,forming cytokine storm,thereby exacerbating tissue damage and disease development.To effectively control inflammatory storm has become a key point in the treatment of patients with COVID-19.Mesenchymal stem cells(MSCs)can effectively control abnormal immune response and inhibit damage to multiple human organs due to the virtue of low immunogenicity and regulating ability to both innate and adaptive immunity.According to the characteristics of immune dysfunction in COVID-19 patients and previous studies,MSCs may have a good effect on treatment of COVID-19.This article focuses on analyzing changes of innate and adaptive immune responses in COVID-19 patients and elucidates the regulation mechanism of MSCs on immunity,in order to provide new insights and theory for clinical immunotherapy in COVID-19 patients.

关 键 词：新型冠状病毒肺炎 免疫功能 间充质干细胞 

分 类 号：R563.1[医药卫生—呼吸系统]