吴斌主任中医师治疗干燥综合征用药规律研究  

On WU Bin’s Medication Rules in the Treatment of Sjogren’s Syndrome

作　　者：王晶[1] 易国祥 李成荫[1] 王莎莎[1] 朱丰林 曹春辉[1] 戴明珠 戴敏[1] WANG Jing;YI Guo-xiang;LI Cheng-yin;Wang Sha-sha;ZHU Feng-lin;CAO Chun-hui;DAI Ming-zhu;Dai Min

机构地区：[1]重庆市中医院,重庆400021 [2]湖南中医药大学,湖南长沙410208

出　　处：《风湿病与关节炎》2021年第5期11-14,共4页Rheumatism and Arthritis

基　　金：国家自然科学基金(81804086);重庆市科研院所绩效激励引导专项(cstc2018jxj1130016,cstc2017jxj1130033);重庆市自然科学基金面上项目(cstc2019jcyj-msxmX0714,cstc2020jcyj-msxmX0404)。

摘　　要：目的:分析吴斌主任中医师治疗干燥综合征的辨证思路与用药规律。方法:收集吴斌主任中医师2012年7月至2019年7月于重庆市中医院门诊治疗干燥综合征的医案,采用IBM SPSS Modeler 18.0统计软件对纳入数据进行频数分析、分层聚类分析、三项关联规则分析,总结处方用药规律。结果:纳入医案共涉及处方901首,药物176味,使用频率>30%的药物17味,有知母、北沙参、芦根、菊花、夏枯草、石膏等。高频药物四气五味以寒性、甘味居首位,归经频率>30%的有肺、胃、肝、脾经。高频药物聚类分析主要分为两大类。结论:吴斌主任中医师治疗干燥综合征的药物以清肝泻胃为主,益气生津为辅。Objective:To analyze WU Bin’s dialectical thought and medication rule in treating Sj?gren’s syndrome.Methods:The medical cases of Sjogren’s syndrome by director WU Bin from July 2012 to July 2019 were collected from Chongqing Hospital of Chinese Medicine.IBM SPSS Modeler 18.0 was used to make frequency analysis,hierarchical cluster analysis and three related rules analysis to summarize the medication rules.Results:Nine hundred and one cases were included.There were 176 drugs,the frequency of 17 drugs of which was more than 30%,including Zhimu(Rhizoma Anemarrhenae),Beishashen(Radix Glehniae),Lugen(Rhizoma Phragmitis),Juhua(Flos Chrysanthemi),Xiakucao(Spica Prunellae),and Shigao(Gypsum Fibrosum).The top-ranking drugs with high frequency are mainly of cold and sweet.The frequency of channel entry of the lung,stomach,liver and spleen channels was more than 30%.High frequency drug cluster analysis is divided into two main categories.Conclusion:Drugs used in WU Bin’s medication are mainly those of clearing liver and descending stomach qi,and supplementing qi and promoting fluid production.

关 键 词：干燥综合征 用药规律 数据挖掘 吴斌 

分 类 号：R249[医药卫生—中医临床基础] R259[医药卫生—中医学]