Fe-Catalyzed Pictet-Spengler-Type Cyclization via Selective Four-Electron Reductive Functionalization of CO_(2)  

作　　者：Wen-Duo Li Jie Chen Dao Yong Zhu Ji-Bao Xia 

机构地区：[1]State Key Laboratory for Oxo Synthesis and Selective Oxidation,Center for Excellence in Molecular Synthesis,Suzhou Research Institute of LICP,Lanzhou Institute of Chemical Physics(LICP),Chinese Academy of Sciences,Lanzhou,Gansu 730000,China [2]University of Chinese Academy of Sciences,Beijing 100049,China

出　　处：《Chinese Journal of Chemistry》2021年第3期614-620,共7页中国化学（英文版）

基　　金：We are grateful to the financial support from NSFC(Nos.21772208,21702212,21602230);the Key Research Program of Frontier Sciences of CAS(No.QYZDJSSW-SLH051).

摘　　要：Main observation and conclusion Herein,we describe a novel catalytic Pictet-Spengler-type cyclization using CO_(2) as a nontoxic and sustainable C1 feedstock with envi-ronmentally benign and non-precious-metal iron as catalyst.The reaction is achieved by selective four-electron reduction of CO_(2) into methylene level intermediate through carefully tuning the reaction parameters.A variety of tetrahydro-B-carbolines and other nitro-gen-containing heterocycles can be easily obtained under mild conditions.Mechanistic studies have shown that tetrahy-dro-B-carbolines are probably obtained via spiroindolenine intermediates.

关 键 词：Carbon dioxide Iron catalysis Four-electron reduction Pictet-Spengler-type cyclization Tetrahydro-B-carboline 

分 类 号：O62[理学—有机化学]