Polyoxygenated Cembranoids from Soft Coral Lobophytum Crassum and Their Anti-tumoral Activities  

作　　者：Fang-Zhou Yin Xia-Juan Huan Wayan Mudianta Ze-Hong Miao Hong Wang Yue-Wei Guo Xu-Wen Li 

机构地区：[1]State Key Laboratory of Drug Research,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,555 Zu Chong Zhi Road,Zhangjiang Hi-Tech Park,Shanghai 201203,China [2]Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals and College of Pharmaceutical Science,Zhejiang University of Technology,Hangzhou,Zhejiang 310014,China [3]Department of Chemistry,Universitas Pendidikan Ganesha,Bali 81116,Indonesia

出　　处：《Chinese Journal of Chemistry》2021年第3期640-646,共7页中国化学（英文版）

基　　金：the National Natural Science Foundation of China(Nos.81991521,81520108028,21672230);the National Key Research and Development Program of China(No.2018YFC0310903);the Drug Innovation Major Pro-ject(No.2018ZX09711-001-001-009);the SKLDR/SIMM Project(No.SIMM1903ZZ-04);the National 111 Project(No.D17012);X.-W.Li is also thankful for the Shanghai Rising-Star Program(No.20QA1411100)and SA-SIBS Scholarship Program.

摘　　要：Main observation and conclusion Four new cembranoids,6-oxo-cembrene-A(1),lobocrassins G-H(2-3),and 14-epi-lobophytolide B(4),along with eight known re-lated compounds(5-12),were isolated from the South China Sea soft coral Lobophytum crassum.Their structures were established by extensive spectroscopic analysis and by comparison of the spectral data with those reported in the literatures.The absolute stere-ochemistry of 14-epi-lobophytolide B(4)was established by time-dependent density functional theory electronic circular dichroism(TDDFT-ECD)calculations,whereas that of three known metabolites(6,11 and 12)was also determined,for the first time,by using modified Mosher's method and/or X-ray diffraction analyses.In bioassay,the cembranoids 6,7 and 12 showed significant an-ti-tumoral activity against A549,HT-29,SNU-398 and Capan-1 tumor cell lines with IC_(50) values ranging from 1.5 to 7.4μmol/L.A pre-liminary structure-activity relationship was also discussed.

关 键 词：Soft coral Lobophytum crassum Cembranoids Anti-tumoral activity STEREOCHEMISTRY 

分 类 号：O6[理学—化学]