Construction of 3-Azabicyclo[3.1.0]hexane Backbone by the Reaction of Allenes with Allylamines via Tandem Michael Addition and Copper-Mediated Oxidative Carbanion Cyclization  

作　　者：Hui Xu Teng Han Xiaoyan Luo Wei-Ping Deng 

机构地区：[1]Shanghai Key Laboratory of New Drug Design and School of Pharmacy,East China University of Science and Technology,130 Meilong Road,Shanghai 200237,China

出　　处：《Chinese Journal of Chemistry》2021年第3期666-670,共5页中国化学（英文版）

基　　金：the Shanghai Comittee of Science and Technology(No.17ZR1407600)。

摘　　要：Main observation and conclusion A facile synthetic method for the construction of 3-azabicyclo[3.1.0]hexane in the presence of copper catalyst system was developed.The reaction proceeds through Michael addition of allylamines with allenes followed by copper-mediated intramolecular oxidative carbanion 5-exo-trig radical cyclization,affording potential biologically active 3-azabicyclo[3.1.O]hexane derivatives in moderate to high yields(42%-85%).

关 键 词：Oxidative coupling ALLENES ALLYLAMINE 3-Azabicyclo[3 1 0]hexane Miachel addition 

分 类 号：O62[理学—有机化学]