弥漫大B细胞性淋巴瘤患者Ki-67、β2-MG、CRP、ESR的水平变化及意义  

Expression and Significance of Ki-67,β2-MG,CRP and ESR in Diffuse Large B-cell Lymphoma

作　　者：张青[1] 李承彬[1] 邓明凤 ZHANG Qing;LI Cheng-bin;DENG Ming-feng(The Second Clinical Medical College of Yangtze University,Jingzhou 434000, China;Department of Laboratory Medicine, Jingzhou Central Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jingzhou 434000, China)

机构地区：[1]长江大学第二临床医学院,荆州434000 [2]华中科技大学同济医学院附属荆州中心医院检验医学部,荆州434000

出　　处：《微循环学杂志》2021年第2期57-61,共5页Chinese Journal of Microcirculation

摘　　要：目的:探讨弥漫大B细胞性淋巴瘤(DLBCL)患者细胞增殖核抗原(Ki-67)、β2微球蛋白(β2-MG)、C反应蛋白(CRP)、红细胞沉降率(ESR)的水平变化及意义。方法:回顾性分析荆州市中心医院2018-01-2020-12收治的121例DLBCL患者病历资料,分析不同临床特征DLBCL患者Ki-67、β2-MG、CRP、ESR水平变化,以及相关指标对高危DLBCL患者的诊断价值。结果:年龄≥60岁患者的β2-MG、ESR水平明显高于年龄<60岁患者;伴有B症状患者的β2-MG、CRP水平高于不伴B症状患者;Ⅲ-Ⅳ期患者的Ki-67、β2-MG水平高于Ⅰ-Ⅱ期患者;IPI评分3-5分患者的β2-MG水平高于IPI评分0-2分患者。β2-MG水平与患者年龄、B症状、分期及IPI评分相关(P<0.01),Ki-67水平与患者临床分期相关(P<0.01),CRP水平与患者B症状、临床分期相关(P<0.05或P<0.01),ESR水平与患者年龄相关(P<0.05),且β2-MG、CRP、ESR三者之间互有相关性(P<0.05或P<0.01)。Ki-67、β2-MG、CRP的诊断高危DLBCL患者ROC曲线下面积(AUC)分别是0.808、0.839、0.654;三者联用时AUC为0.909。结论:Ki-67、β2-MG、CRP联合检测可提高高危DLBCL患者的诊断敏感性。Objective:To investigate the expression and significance of cell proliferating nuclear antigen(Ki-67),β2-microglobulin(β2-MG),C-reactive protein(CRP)and erythrocyte sedimentation rate(ESR)in diffuse large B-cell lymphoma(DLBCL).Method:The medical records of 121 DLBCL patients from January 2018 to December 2020 were retrospectively reviewed.The changes of Ki-67,β2-MG,CRP and ESR levels in DLBCL patients with different clinical characteristics,and the diagnostic value of related inicators for high-risk DLBCL patients were analyzed.Results:The level ofβ2-MG and ESR in patients aged≥60 years were significantly higher than those in patients aged<60 years.The level ofβ2-MG and CRP in patients with B symptoms were higher than those in patients without B symptoms.The Ki-67 andβ2-MG levels of stage III-IV patients were higher than those of stage I-II patients.Patients with an IPI score of 3-5 had higher levels ofβ2-MG than those with an IPI score of 0-2.β2-MG level was correlated with age,B symptoms and IPI score(P<0.01).CRP level was correlated with patient's B symptom and clinical stage(P<0.05 or P<0.01).ESR level was related to the patient's age(P<0.05).β2-MG,CRP,ESR wre related to each other(P<0.05 or P<0.01).The AUC of the area under the ROC curve of Ki-67,β2-MG,and CRP were 0.808,0.839,0.654,respectively.When the three were used in combination,the AUC was 0.909.Conclusion:The combined use of Ki-67,β2-MG and CRP can improve the diagnostic sensitivity of DLBCL.

关 键 词：弥漫大B细胞性淋巴瘤 细胞增殖核抗原 Β2微球蛋白 C反应蛋白 

分 类 号：R446.1[医药卫生—诊断学]