川芎挥发油羟丙基-β-环糊精包合物的制备及其性能研究  

Preparation and property study of hydroxypropyl-β-cyclodextrin inclusion complex of Chuanxiong Rhizoma volatile oil

作　　者：杨玉婷 刘云华[2] 刘玉红[2] 黄志芳[2] 陈燕[2] 易进海 YANG Yu-ting;LIU Yun-hua;LIU Yu-hong;HUANG Zhi-fang;CHEN Yan;YI Jin-hai(School of Pharmacy,Chengdu University of Traditional Chinese Medicine,Chengdu 611137,China;Sichuan Provincial Key Laboratory of Quality and Innovation Research of Chinese Materia Medica,Sichuan Academy of Chinese Medicine Sciences,Chengdu 610041,China)

机构地区：[1]成都中医药大学药学院,成都611137 [2]四川省中医药科学院中药材品质及创新中药研究四川省重点实验室,成都610041

出　　处：《天然产物研究与开发》2021年第5期734-742,共9页Natural Product Research and Development

基　　金：国家“重大新药创制”科技重大专项(2018ZX09201018-029);四川省科技厅基本科研业务专项(A-2020N-26,A-2018N-10)。

摘　　要：制备川芎挥发油羟丙基-β-环糊精(hydroxypropyl-β-cyclodextrin,HP-β-CD)包合物,提高川芎挥发油的溶解度及稳定性。采用单相法制备包合物,以包合率为评价指标,正交试验法优选包合工艺条件。运用扫描电镜(SEM)和红外光谱(IR)进行表征,对包合物进行溶解度和稳定性考察。采用单相法制备该包合物的最优工艺条件为乙醇体积分数95%,挥发油∶HP-β-CD(W/W)=1∶10,HP-β-CD∶乙醇(W/V)=1∶3,包合率达92.34%。表征结果表明包合物已形成,HP-β-CD使川芎挥发油溶解度显著提高,包合物在60℃条件下10天稳定性良好。优选的包合工艺重现性好、包合率高,制备方法简便高效,能显著提高川芎挥发油的溶解度及稳定性。To improve the poor solubility and stability,Chuanxiong Rhizoma volatile oil-hydroxypropyl-β-cyclodextrin(HP-β-CD)inclusion complex was prepared.It was prepared by single-phase method,taking the inclusion rate as evaluation index,and the inclusion process conditions were optimized by orthogonal test.The inclusion complex was characterized by SEM and IR,as well as,the solubility and stability were evaluated.The optimal process conditions for single-phase method to prepare the inclusion complex were as follows:Ethanol concentration:95%,volatile oil∶HP-β-CD(W/W)=1∶10,HP-β-CD∶ethanol(W/V)=1∶3,the inclusion rate reached 92.34%.The characterization results showed that the inclusion complex had been formed,HP-β-CD significantly improved the solubility of Chuanxiong Rhizoma volatile oil,in addition,the inclusion complex had good stability at 60℃for 10 days.The optimized inclusion process of HP-β-CD inclusion complex of Chuanxiong Rhizoma volatile oil is simple and efficient with good reproducibility and high inclusion rate,which could significantly improve the solubility and stability of Chuanxiong Rhizoma volatile oil.

关 键 词：川芎挥发油 羟丙基-Β-环糊精 包合物 溶解度 稳定性 

分 类 号：R932[医药卫生—生药学]