血清髓样细胞触发受体-1、可溶性白细胞介素-2受体水平变化对脑梗死继发肺部感染的预测价值及与神经功能、细胞免疫相关性  

Predictive value of serum sTREM-1 and SIL-2R levels in pulmonary infection secondary to cerebral infarction and its correlation with neurological function and cellular immunity

作　　者：忻燕 戎月珍 杨莉 XIN Yan;RONG Yue-zhen;YANG Li(Department of Neurology,Ningbo Medical Center Li Huili Hospital,Ningbo,Zhejiang 315000,China)

机构地区：[1]宁波市医疗中心李惠利医院神经内科,浙江宁波315000

出　　处：《中国卫生检验杂志》2021年第8期978-982,共5页Chinese Journal of Health Laboratory Technology

摘　　要：目的探究血清髓样细胞触发受体-1(sTREM-1)、可溶性白细胞介素-2受体(SIL-2R)水平变化对脑梗死继发肺部感染的预测价值及与神经功能、细胞免疫相关性。方法选取2017年10月-2019年10月本院35例脑梗死继发肺部感染患者作为研究组,纳入同期43例脑梗死患者作为对照组。对比2组血清sTREM-1、SIL-2R水平、神经功能(NIHSS)、细胞免疫(CD4^(+)、CD8^(+)、CD3^(+)),并分析脑梗死继发肺部感染的影响因素、血清sTREM-1、SIL-2R对脑梗死继发肺部感染预测价值及与神经功能、细胞免疫因子相关性。结果研究组入院时、入院48 h血清SIL-2R、sTREM-1水平高于对照组(P<0.05);入院48 h血清sTREM-1预测脑梗死继发肺部感染的AUC>入院48 h SIL-2R>入院时sTREM-1、SIL-2R;血清sTREM-1、SIL-2R水平异常均为脑梗死继发肺部感染的高危因素(P<0.05);研究组入院48 h NIHSS、血清CD8^(+)水平高于对照组,血清CD4^(+)、CD3^(+)水平低于对照组,上述差异均有统计学意义(P<0.05);血清SIL-2R、sTREM-1水平与NIHSS、血清CD8^(+)水平呈正相关(P<0.05),与CD4^(+)、CD3^(+)水平呈负相关(P<0.05)。结论血清sTREM-1、SIL-2R水平异常升高为脑梗死继发肺部感染的高危因素,且与神经功能、细胞免疫具有密切相关性,对脑梗死继发肺部感染具有较高预测价值,监测其水平变化可为临床制定针对性治疗方案提供重要参考。Objective To investigate the value of serum myeloid cell triggered receptor-1(sTREM-1)and soluble interleukin-2 receptor(SIL-2 R)levels in predicting the secondary pulmonary infection of cerebral infarction and its correlation with nerve function and cellular immunity.Methods From October 2017 to October 2019,35 patients with secondary cerebral infarction and pulmonary infection in our hospital were selected as the research group,and 43 patients with cerebral infarction during the same period were included as the control group.The serum levels of sTREM-1,SIL-2 R levels,neurological function(NIHSS),cellular immunity(CD4^(+),CD8^(+),CD3^(+))were compared between the two groups,and analyzed the influencing factors of secondary pulmonary infection in cerebral infarction,serum sTREM-1,SIL-2 R on the predictive value of secondary pulmonary infection in cerebral infarction and its correlation with nerve function and cellular immune factors.Results The serum SIL-2 R and sTREM-1 levels of the study group at admission and 48 hours after admission were higher than those of the control group(P<0.05);serum sTREM-1 at 48 hours after admission to predict the AUC of secondary pulmonary infection in cerebral infarction>SIL-2 R at admission 48 h>sTREM-1,SIL-2 R at admission;abnormal levels of serum sTREM-1 and SIL-2 R were high-risk factors for secondary pulmonary infection in cerebral infarction(P<0.05);the NIHSS and serum CD8^(+)levels in the study group were higher than those in the control group at 48 h after admission,and the serum CD4^(+)and CD3^(+)levels were lower than the control group,with the difference statistically significant(P<0.05);serum SIL-2 R and sTREM-1 levels were positively correlated with NIHSS and serum CD8^(+)levels(P<0.05),and negatively correlated with CD4^(+)and CD3^(+)levels(P<0.05).Conclusion Abnormally elevated serum sTREM-1 and SIL-2 R levels are high-risk factors for secondary pulmonary infection in cerebral infarction,and are closely related to nerve function and cellular immunity,and have high pr

关 键 词：脑梗死 肺部感染 髓样细胞触发受体-1 可溶性白细胞介素-2受体 神经功能 细胞免疫 

分 类 号：R563.1[医药卫生—呼吸系统]