粪便钙卫蛋白联合血清学抗体检测诊断炎症性肠病的临床应用价值  

The diagnostic utility of fecal calprotectin used in combination with an antibody against chronic inflammatory bowel disease

作　　者：高丹[1] 王科峰[2] 卢丽萍[1] GAO Dan;WANG Kefeng;LU Liping(Department of Clinical Laboratory,Shengjing Hospital of China Medical University,Shenyang 110004,China;Department of Urology Surgery,Shengjing Hospital of China Medical University,Shenyang 110004,China)

机构地区：[1]中国医科大学附属盛京医院检验科,沈阳110004 [2]中国医科大学附属盛京医院泌尿外科,沈阳110004

出　　处：《中国医科大学学报》2021年第5期425-428,共4页Journal of China Medical University

基　　金：辽宁省重点研发计划联合计划(2020JH2/10300139);辽宁省自然科学基金(2019-MS-360)。

摘　　要：目的探讨粪便钙卫蛋白(FC)联合血清炎症性肠病(IBD)相关抗体检测IBD的临床应用价值。方法回顾性分析2019年3月至2020年3月中国医科大学附属盛京医院消化内科收治的106例肠道疾病患者FC和慢性IBD抗体检测结果。将106例患者以病理检查及肠镜检查为金标准分为溃疡性结肠炎(UC)组(64例)和克罗恩病(CD)组(42例),另选取同期30例健康体检者作为对照组。绘制FC、慢性IBD抗体及联合检测诊断IBD的受试者工作特征(ROC)曲线,评价诊断价值。结果FC、慢性IBD抗体及联合检测诊断IBD的ROC曲线下面积分别为0.859、0.583、0.828,FC诊断IBD准确性更高。在IBD诊断方面,FC+慢性IBD抗体检测灵敏度(90.6%)和阴性预测值(73.0%)高于2项指标单独检测;FC单独检测特异性(91.7%)和阳性预测值(96.6%)高于慢性IBD抗体单独检测及FC+慢性IBD抗体联合检测。结论FC、慢性IBD抗体联合检测可以提高检测的敏感性,在IBD的诊断中具有重要的临床应用价值。Objective To investigate the clinical utility of fecal calprotectin(FC)used along with serum inflammatory bowel disease(IBD)-related antibody in the diagnosis of IBD.Methods We retrospectively analyzed the FC and chronic IBD antibody test results of 106 patients with intestinal disease admitted to the Department of Gastroenterology,Shengjing Hospital,China Medical University between March 2019 and March 2020.The patients were divided into two groups based on the findngs of pathological examination and colonoscopy.There were 64 cases of ulcerative colitis(UC)and 42 cases of Crohn disease(CD).Thirty healthy people were selected as the control group in the same period.Results The area under the ROC curves when using FC,the antibody against chronic IBD,and both FC and the antibody were 0.859,0.583,and 0.828,respectively.FC is more accurate than the other two methods in the diagnosis of IBD.In the diagnosis of IBD,the sensitivity(90.6%)and negative predictive value(73.0%)of FC+the chronic IBD antibody were higher than those of the two indicators used separately,while the specificity(91.7%)and positive predictive value(96.6%)of FC single detection were higher than those of the single detection of chronic IBD antibody and the combined detection of FC+chronic IBD antibody.Conclusion The combination of both FC and the antibody is clinically useful in the diagnosis of chronic IBD as it could improve the sensitivity of detection of IBD.

关 键 词：粪便钙卫蛋白 炎症性肠病 慢性炎症性肠病抗体 

分 类 号：R446.12[医药卫生—诊断学]