高效绿色高选择性的Knoevenagel缩合反应研究进展  

Research Progress on Knoevenagel Condensation with High Efficiency,Green and High Selectivity

作　　者：李冬梅[1] 马文静 LI Dong-mei;MA Wen-jing(Jiangsu Agri-animal Husbandry Vocational College,Jiangsu Taizhou 225300,China)

机构地区：[1]江苏农牧科技职业学院,江苏泰州225300

出　　处：《广州化工》2021年第10期11-13,45,共4页GuangZhou Chemical Industry

基　　金：江苏农牧科技职业学院科研项目(NSFHP201904)。

摘　　要：Knoevenagel缩合反应是增长碳链的常见经典缩合反应之一。本文主要介绍了近年来研究较热的有机胺(盐)催化剂、金属离子催化剂、各种功能性有机碱性催化剂,在离子液体作为介质,水甚至无溶剂条件下,常规加热、微波、研磨作用下的绿色、高效、高选择性的Knovenagel缩合反应的研究进展。该反应提供了一种含活泼亚甲基类化合物生成α,β-不饱和羰基化合物及其类似物的可靠途径。Knoevenagel condensation is one of the classical condensation reactions for the growth of carbon chain.The research progress on the green,efficient and highly selective knovenagel condensation reactionwas mainly introduced under the action of conventional heating,microwave and grinding in ionic liquid as medium,water or even solvent-free,which were hot organic amine(salt)catalyst,metal ion catalyst and various functional organic basic catalyst.This reaction provided a reliable way for the formation ofα,β-unsaturated carbonyl compounds and their analogues.

关 键 词：KNOEVENAGEL缩合 离子液体 催化剂 活泼亚甲基 芳醛 

分 类 号：O621.25[理学—有机化学]