美洲大蠊提取物胃漂浮缓释片制备研究  

Preparation of Intragastric Floating Sustained-Release Tablets of Periplaneta Americana Extract

作　　者：王旭 WANG Xu(Yunnan Provincial Key Laboratory of Entomological Biopharmaceutical R&D(Dali University),College of Pharmacy,Dali University,Yunnan Dali 671000,China)

机构地区：[1]云南省昆虫生物医药研发重点实验室(大理大学),大理大学药学院,云南大理671000

出　　处：《广州化工》2021年第10期70-73,共4页GuangZhou Chemical Industry

摘　　要：以假酸浆子胶质为片剂辅料制备美洲大蠊提取物胃漂浮缓释片。在单因素试验的基础上,以美洲大蠊提取物胃漂浮缓释片中尿嘧啶体外释放百分率为评价指标进行正交试验优化美洲大蠊提取物胃漂浮缓释片处方。优化处方为美洲大蠊提取物10 g,羟丙甲基纤维素K100M 22 g,假酸浆子胶质冻干品4 g,十八醇12 g,乙基纤维素12 g,1%硬脂酸镁。应用假酸浆子胶质制备的美洲大蠊提取物胃漂浮缓释片制备方法简单可行。To prepare intragastric floating sustained-release tablets of Periplaneta americana extract with gum from Nicandra physaloides(L.)Gaertn seeds(GNPS)as tablet excipient.Based on single factor test,the orthogonal experiment was conducted to optimize the formulation of intragastric floating sustained-release tablets of Periplaneta americana extract(GFSRTPA),using the percentage released in vitro uracil in GFSRTPA as evaluation indexes.The optimal formulation of GFSRTPA was made up of Periplaneta americana extract 10 g,HPMC K100M 22 g,GNPS 4 g,octadecanol 12 g,ethylcellulose 12 g,1%magnesium stearate.The prepared method of GFSRTPA with GNPS is simple and feasible.

关 键 词：美洲大蠊提取物 假酸浆子胶质 胃漂浮缓释片 制备 

分 类 号：R9[医药卫生—药学]