基于数据挖掘探究中医临床专家防治新型冠状病毒肺炎用药规律  

Prescription Characteristics of TCM Clinicians for Corona Virus Disease 2019 Based on Data mining

作　　者：孙凡雅 张会永[2] 宋芷琪 张静生[2] SUN Fanya;ZHANG Huiyong;SONG Zhiqi;ZHANG Jingsheng(Liaoning University of Traditional Chinese Medicine,Shenyang 110847,Liaoning,China;Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang 110032,Liaoning,China)

机构地区：[1]辽宁中医药大学,辽宁沈阳110847 [2]辽宁中医药大学附属医院,辽宁沈阳110032

出　　处：《辽宁中医药大学学报》2021年第4期112-117,共6页Journal of Liaoning University of Traditional Chinese Medicine

基　　金：第六批全国老中医药专家学术经验继承工作实施项目(国中医药人教发[2017]29号);全国名老中医药专家传承工作室建设项目(国中医药人教发[2011]41号)。

摘　　要：目的探究中医专家在新型冠状病毒肺炎(简称"新冠肺炎")预防和治疗中的用药规律,为临床防治新冠肺炎提供思路和依据。方法收录2020年1月21日—2020年2月22日,中医临床专家对新冠肺炎防治的不同见解,分为预防期和治疗期建立数据库。应用SPSS 21.0和SPSS Clementine 10.1软件统计中药及其性、味、归经频次,并进行聚类分析,应用Apriori算法挖掘关联规则并绘制关联网络图。结果收录预防类处方26首,涉及中药共73味,高频药物为金银花、藿香、甘草、连翘、苍术,以清热、补益药应用最多,主要入肺、胃经,药味多甘、苦,药性多寒、温。关联网络图最核心的药物组成为黄芪、桔梗、芦根、荆芥、金银花、连翘。治疗类处方收录37首,涉及中药共96味,高频药物为甘草、人参、杏仁、半夏、厚朴,以清热、化湿、化痰止咳平喘药应用最多,主入肺、胃经,药味多甘、辛,药性多寒。关联规则核心药物为草果、槟榔、茯苓、白术、石膏、大黄。预防期和治疗期在聚类分析后各得到新方5首。结论中医在新冠肺炎临床防治中用药以入肺经为主,兼调脾胃。在新冠肺炎预防期,治法以清热燥湿为主,辅以益气固表,常见组方为银翘散和藿香正气散。在新冠肺炎治疗期常见组方为达原饮。预防期处方分析后所得新方以清热解表、燥湿健脾为主,治疗期处方分析后所得新方以清热泻火、燥湿化痰为主。Objective To explore the prescription characteristics of TCM clinical experts for the prevention and treatment of corona virus disease 2019(COVID-19)with traditional Chinese medicine,provide mentality and basis for clinical prevention and treatment. Methods The study collected different opinions of TCM clinical experts on the prevention and treatment of COVID-19 from January 21,2020 to February 22,2020. The opinions were divided into prevention period and treatment period and set up databases.The SPSS 21.0 and SPSS Clementine 10.1 were used to analyze the frequency and cluster analysis of herbs;analyze the association rules with Apriori algorithm;plot the associated network diagram. Results 26 preventive prescription with 73 herbs were included. The high-frequency medicines in the prescription were Jinyinhua(Lonicerae Japonicae Flos),Huoxiang(Pogostemonis Herba),Gancao(Glycyrrhizae Radix Et Rhizoma),Lianqiao(Forsythiae Fructus),Cangzhu(Atractylodis Rhizoma). They were mostly antipyretic and tonic drugs with warm and cold nature. They mostly had sweet or bitter taste,belong to the stomach and lung meridians. The core composition of the association network were Huangqi(Astragali Radix),Jiegeng(Platycodonis Radix),Lugen(Phragmitis Rhizoma),Jingjie(Schizonepetae Herba),Jinyinhua(Lonicerae Japonicae Flos),Lianqiao(Forsythiae Fructus). Five new prescriptions were mined by cluster analysis in prevention. There were 37 therapeutic prescriptions involving 96 herbs of which the high-frequency ones were Gancao(Glycyrrhizae Radix Et Rhizoma),Renshen(Ginseng Radix Et Rhizoma),Xingren(Armeniacae Semen Amarum),Banxia(Pinelliae Rhizoma),Houpo(Magnoliae Officinalis Cortex). They were mostly antipyretic, dampness resolving,phlegm relieving and antiasthmatic drugs with cold nature. They mostly had sweet and spicy taste,belong to the stomach and lung meridians. The core medicine of association rules were Caoguo(Tsaoko Fructus),Binglang(Arecae Semen),Fuling(Poria),Baizhu(Atractylodis Macrocephalae Rhizoma),Shigao(Gypsum Fibrosum),Dah

关 键 词：新型冠状病毒肺炎 数据挖掘 聚类分析 关联规则 用药规律 

分 类 号：R563.1[医药卫生—呼吸系统]