香菇多糖注射液结合吉非替尼对非小细胞肺癌疗效、肺功能、不良反应影响研究  

Effects of Lentinan Injection Combined with Gefitinib on Efficacy, Lung Function and Side Effects of Non-Small Cell Lung Cancer Patients

作　　者：李勤 张嫚 孟祥珍 LI Qin;ZHANG Man;MENG Xiangzhen(First Affiliated Hospital of Kangda College,Nanjing Medical University,Lianyungang 222000,Jiangsu,China)

机构地区：[1]南京医科大学康达学院第一附属医院,江苏连云港222000

出　　处：《中华中医药学刊》2021年第4期163-166,共4页Chinese Archives of Traditional Chinese Medicine

基　　金：江苏省自然科学基金(BK20181227)。

摘　　要：目的探究香菇多糖注射液结合吉非替尼对非小细胞肺癌患者疗效、肺功能、不良反应影响。方法共计纳入非小细胞肺癌患者104例,均由医院2016年5月—2019年8月收治,根据治疗方法不同以随机数字表法将以上患者分为对照组以及观察组,对照组患者(52例)采取吉非替尼治疗,观察组患者(52例)采取吉非替尼联合香菇多糖注射液治疗,比较两组患者近期疗效、中医证候疗效、症状(咳嗽、疼痛、厌食、乏力等)缓解时间、治疗前后患者肺功能指标变化、治疗后两组患者外周血促炎性细胞因子白介素1β(IL-1β)、肿瘤坏死因子α(TNF-α)水平、治疗前后免疫球蛋白指标变化及T淋巴细胞水平变化、生活质量改善情况、不良反应情况。结果观察组患者治疗近期总有效率(73.08%,38/52)高于对照组(53.85%,28/52)(P<0.05);观察组患者中医证候疗效有效率(75.00%,39/52)高于对照组(50.00%,26/52)(P<0.05);观察组患者症状缓解时间短于对照组(P<0.01);治疗前,两组患者用力肺活量(FVC)、第1秒用力呼气容积(FEV1)水平比较(P>0.05);治疗后各组患者FVC、FEV1水平均改善,观察组改善优于对照组(P<0.05);治疗后观察组患者IL-1β、TNF-α水平均低于对照组(P<0.05);治疗前,两组患者IgA、IgG、IgM免疫球蛋白指标、CD^(+)_(3)、CD^(+)_(4)、CD^(+)_(8)、CD^(+)_(4)/CD^(+)_(8)水平比较(P>0.05);治疗后各组患者IgA、IgG、IgM、CD^(+)_(3)、CD^(+)_(4)、CD^(+)_(8)、CD^(+)_(4)/CD^(+)_(8)水平等指标均改善,观察组优于对照组(P<0.05);观察组患者治疗后生活质量改善率(90.38%,47/52)高于对照组(71.15%,37/52)(P<0.05);观察组患者不良反应率(3.85%,2/52)低于对照组(21.15%,11/52)(P<0.05)。结论香菇多糖注射液结合吉非替尼对非小细胞肺癌疗效确切,患者近期疗效佳,症状改善,恢复好,恢复快,且患者肺功能、免疫功能一定程度改善,且患者生活质量改善,不良反应率低,安全性高,值得推广Objective To explore the effects of Lentinan Injection combined with gefitinib on the efficacy, lung function and side effects of non-small cell lung cancer patients. Methods A total of 104 cases with non-small cell lung cancer patients from May 2016 to August 2019, according to the different treatment method with random number table method, were divided into control group and observation group. The control group (52 cases) was given gefitinib. The observation group (52 cases) added Lentinan Injection. We compared two groups’ near curative effect, alleviating time of TCM symptoms, cough, pain, anorexia and fatigue, pulmonary function index changes of the patients before and after treatment. In two groups after treatment, levels of inflammatory cytokine interleukin 1 beta (IL-1 beta), tumor necrosis factor alpha (TNF-α),immune globulin and T lymphocyte before and after treatment, and the quality of life and side effects were compared. Results The total effective rate (73.08%,38/52) in the observation group was higher than that in the control group (53.85%,28/52) (P<0.05). The effective rate of TCM syndromes in the observation group (75.00%,39/52) was higher than that in the control group (50.00%,26/52) (P<0.05). The remission time of symptoms in the observation group was shorter than that in the control group (P<0.01). Before treatment, the levels of forced vital capacity (FVC) and forced expiratory volume (FEV1) were compared between the two groups (P>0.05). FVC and FEV1 were improved in both groups after treatment, and the improvement in the observation group was better than that in the control group (P<0.05). After treatment, the levels of IL-1 and TNF-α in the observation group were lower than those in the control group (P<0.05). Before treatment, the levels of IgA, IgG and IgM, CD^(+)_(3), CD^(+)_(4), CD^(+)_(8) and CD^(+)_(4)/CD^(+)_(8) in the two groups were not significant (P>0.05). After treatment, levels of IgA, IgG, IgM, CD^(+)_(3), CD^(+)_(4), CD^(+)_(8) and CD^(+)_(4)/CD^(+)_(8) were improved in b

关 键 词：非小细胞肺癌 吉非替尼 香菇多糖注射液 疗效 肺功能 不良反应 

分 类 号：R277.734.2[医药卫生—中医学]