动脉粥样硬化指数和血小板参数在血脂异常痰浊阻遏证中的临床意义  

Clinical Significance of Atherosclerosis Index and Platelet Parameters in Dyslipidemia

作　　者：徐方艳 韩子华 付华美 李萍[1] 董兴红 矫金玲[1] XU Fangyan;HAN Zihua;FU Huamei;LI Ping;DONG Xinghong;JIAO Jinling(Jiangnan Hospital Affiliated to Zhejiang Chinese Medical University,Xiaoshan 311201,Zhejiang,China;Taizhou Enze Medical Center(Group),Taizhou 318050,Zhejiang,China)

机构地区：[1]浙江中医药大学附属江南医院,浙江萧山311201 [2]浙江省台州恩泽医疗中心(集团)恩泽医院,浙江台州318050

出　　处：《中华中医药学刊》2021年第4期244-247,共4页Chinese Archives of Traditional Chinese Medicine

基　　金：浙江省中医药科技计划(2016ZB107)。

摘　　要：目的探讨动脉粥样硬化指数和血小板参数在血脂异常痰浊阻遏证中的临床意义。方法选择2017年1月—2019年3月医院接诊的血脂异常痰浊阻遏证患者90例(病例组)和相同时间内到医院体检的健康者90例(对照组)的资料进行回顾性分析,对比两组一般临床资料,对比两组的血脂,动脉粥样硬化指数,血小板计数,平均血小板体积。利用多因素分析的方法,筛选血脂异常的独立影响因素。分析动脉粥样硬化指数与各项指标的相关性。分析中医症候积分与各项指标的相关性。结果两组的性别、年龄、心率、舒张压的数据差异均不具有统计学意义(χ^(2)=0.252,t=-0.194,-0.512,1.787,P>0.05),病例组的BMI、收缩压高于对照组(t=8.005,8.458,P<0.05),两组的血小板计数、血小板平均体积的数据差异均不具有统计学意义(t=-0.700,0.190,P>0.05),病例组的动脉粥样硬化指数、总胆固醇、甘油三酯、低密度脂蛋白高于对照组,高密度脂蛋白低于对照组(t=10.079,3.799,5.957,-6.693,11.285,P<0.05),患者的BMI偏高,动脉粥样硬化指数偏高,血小板平均体积偏大,均成为患者出现血脂异常的独立危险因素(OR=1.120,1.384,1.048,P<0.05),动脉粥样硬化指数与甘油三酯、血小板平均体积呈正相关,与高密度脂蛋白呈负相关(r=0.378,-0.486,0.543,P<0.05),中医症候积分与动脉粥样硬化指数、甘油三酯、血小板计数、血小板平均体积呈正相关(r=0.432,0.423,0.681,0.571,P<0.05)。结论动脉粥样硬化指数与血小板参数均会在血脂异常痰浊阻遏证患者中产生明显的变化,两种指标对于患者的疾病诊断和病情推断具有一定的指导意义,但尚需要进行深入的研究。Objective To explore the clinical significance of atherosclerosis index and platelet parameters in dyslipidemia.Methods The data of 90 patients (case group) who were turbidity and obstruction syndrome in our hospital from January 2017 to March 2019 and 90 healthy subjects who received physical examination in our hospital during the same period were retrospectively reviewed.The general clinical data of the two groups of patients was compared. Blood lipids, atherosclerosis index, platelet count and mean platelet volume were compared between the two groups. Multivariate analysis was used to screen the independent influencing factors of dyslipidemia. The correlation between the atherosclerosis index and various indicators was analyzed.We analyzed the correlation between TCM symptom scores and various indicators.Result There were no statistically significant differences in gender, age, heart rate or diastolic blood pressure between the two groups (χ^(2)=0.252, t=-0.194,-0.512, 1.787, P>0.05). The BMI and systolic blood pressure in the case group were higher than those in the control group (t=8.005, 8.458, P<0.05). There were no statistically significant differences in platelet counts and mean platelet volume between the two groups (t=-0.700, 0.190, P>0.05). The atherosclerosis index, total cholesterol, triglyceride and low density lipoprotein in the case group were higher than those in the control group, and the high density lipoprotein was lower than that of the control group (t=10.079, 3.799, 5.957,-6.693, 11.285, P<0.05). Patients’ high BMI, high atherosclerosis index and large mean platelet volume were independent risk factors for dyslipidemia (OR=1.120, 1.384, 1.048, P<0.05). The atherosclerosis index was positively correlated with the triglyceride and platelet mean volume, and negatively correlated with high density lipoprotein (r=0.378,-0.486, 0.543, P<0.05). TCM syndrome scores were positively correlated with atherosclerosis index, triglyceride, platelet count, and platelet mean volume (r=0.432, 0.423, 0.68

关 键 词：动脉粥样硬化指数 血小板 血脂异常 中医 

分 类 号：R259.892[医药卫生—中西医结合]