血清hs-CRP、PCT及T细胞亚群在支原体肺炎中的表达及穿心莲内酯磺化物干预的临床疗效  

Expressions of Serum hs-CRP,PCT and T Cell Subsets in Children with Mycoplasma Pneumonia and Clinical Efficacy of Andrographolide Sulfonate Intervention

作　　者：张云霞[1] 王征军[1] 阮联英[1] 张翠翠[1] 张高寅[1] 韩冰[1] 于晓 ZHANG Yunxia;WANG Zhengjun;RUAN Lianying;ZHANG Cuicui;ZHANG Gaoying;HAN Bing;YU Xiao(Xingtai Peopled Hospital,Xingtai 054900,Hebei,China)

机构地区：[1]邢台市人民医院,河北邪台054000

出　　处：《中华中医药学刊》2021年第4期255-258,共4页Chinese Archives of Traditional Chinese Medicine

基　　金：河北省卫生与计划生育委员会项目(20191700)。

摘　　要：目的探讨穿心莲内酯磺化物(ADS)对支原体肺炎(MPP)患儿的干预效果及对血清超敏C-反应蛋白(hs-CRP)、降钙素原(PCT)、T细胞亚群CD^(+)_(3)、CD^(+)_(16)、CD^(+)_(19)的影响。方法选择2017年6月—2019年4月医院收治并确诊的MPP患儿68例,比较根据入院顺序编号并随机分为常规组(常规西药治疗)、ADS干预组(常规西药+ADS),每组34例,并随机选择同时期内于医院体检确诊健康儿童20例作为对照组,比较3组hs-CRP、PCT、T细胞亚群水平;均治疗7d后,比较常规组和干预组临床疗效指标(有效率、无效率、临床症状消失时间)、相关血清因子(hs-CRP、PCT、CD^(+)_(3)、CD^(+)_(16)、CD^(+)_(19))、总不良反应率,并分析hs-CRP、PCT、T细胞亚群水平与MPP临床症状相关性。结果对照组hs-CRP、PCT低于干预组、常规组(P<0.05),CD^(+)_(3)、CD^(+)_(16)、CD^(+)_(19)高于干预组、常规组(P<0.05);治疗后各时间段两组hs-CRP、PCT、CD^(+)_(3)、CD^(+)_(16)、CD^(+)_(19)优于治疗前(P<0.05),且干预组hs-CRP、PCT、CD^(+)_(3)、CD^(+)_(16)、CD^(+)_(19)优于常规组(P<0.05);干预组hs-CRP、PCT下降程度高于常规组,CD^(+)_(3)、CD^(+)_(16)、CD^(+)_(19)上升程度高于常规组;干预组临床症状消失时间、住院时间、无效率和不良反应率低于常规组(P<0.05);CD^(+)_(3)、CD^(+)_(16)、CD^(+)_(19)与MPP临床正常呈显著正相关(P<0.05);hs-CRP、PCT与MPP临床正常呈显著负相关(P<0.05)。结论hs-CRP、PCT、T细胞亚群水平与MPP密切相关,ADS可显著降低上述血清因子而提高免疫功能和临床疗效,且安全性高、不良反应少。Objective To investigate the effect of andrographolide sulfonate(ADS)intervention on expression levels of serum high sensitivity C-reactive protein(hs-CRP),procalcitonin(PCT)and T cell subsets(CD^(+)_(3),CD+(16),CD^(+)_(19))in children with mycoplasma pneumonia(MPP).Methods Sixty-eight MMP children and 20 cases of healthy children(control group)treated in our hospital from June 2017 to April 2019 were enrolled,and MMP children were divided into two groups according to the admission order,each with 34 cases.The routine group received the western medicine,while the intervention group received western medicine combined with ADS.Levels of hs-CRP,PCT,CD^(+)_(3),CD+(16)and CD^(+)_(19)were detected and compared among groups,and their correlation with the clinical symptoms of MPP was also determined.Then the efficacy rate,inefficiency rate and disappearance time of clinical symptoms were compared.Results Among three groups,the levels of serum hs-CRP and PCT were the lowest in the control group,and the levels of CD^(+)_(3),CD+(16),and CD^+_(19)were the highest in the control group,with statistic difference(P<0.05).The levels of hs-CRP,PCT,CD^(+)_(3),CD+(16)and CD^(+)_(19)were improved in MMP children after treatment(P<0.05),and were better in the intervention group than those in the routine group(P<0.05).The decrease of hs-CRP and PCT along with the increase of CD^(+)_(3),CD+(16)and CD^(+)_(19)were more obvious in the intervention group than those in the control group(P<0.05).The disappearance time of clinical symptoms,hospitalization time,inefficiency rate and adverse reactions in the intervention group were lower than those in the routine group(P<0.05).Clinical symptoms of MMP were positively correlated with CD^(+)_(3),CD+(16)and CD^(+)_(19)and were negatively correlated with hs-CRP and PCT(P<0.05).Conclusion Serum hs-CRP,PCT and T cell subsets are closely related to MPP,and the application of ADS can effectively and safely ameliorate the related factors and immune function,with few adverse reactions.

关 键 词：HS-CRP PCT T细胞亚群 MPP 穿心莲内酯磺化物 干预 

分 类 号：R259.631[医药卫生—中西医结合]