自拟方调经止痛丸治疗子宫内膜异位症的效果及安全性观察  

Observation on Effects and Safety of Self-Made Tiaojing Zhitong Pill (自拟调经止痛丸) in Treatment of Endometriosis

作　　者：陈秀英[1] 陈娜[1] 高娜 崔建涛 李晓丹 张玉丽 张士表[1] CHEN Xiuying;CHEN Na;GAO Na;CUI Jiantao;LI Xiaodan;ZHANG Yuli;ZHANG Shibiao(First Department of Gynecology,Cangzhou Integrated Traditional Chinese and Western Medicine Clinical Medical College of Hebei Medical University,Cangzhou 061000,Hebei,China)

机构地区：[1]河北医科大学沧州中西医结合临床医学院,河北沧州061000

出　　处：《辽宁中医杂志》2021年第2期117-120,共4页Liaoning Journal of Traditional Chinese Medicine

摘　　要：目的观察自拟方调经止痛丸治疗子宫内膜异位症(EMT)的效果及安全性。方法选取该院收治的150例EMT患者为研究对象,根据随机原则分为对照组和研究组,对照组69例予以孕三烯酮口服治疗,研究组81例予以自拟方调经止痛丸联合孕三烯酮口服治疗,治疗6个月,观察两种治疗方法对EMT患者临床疗效、中医证候积分(疼痛、经血夹块、盆腔结节、腰膝酸软)以及血清标志物[单核细胞趋化蛋白-1(MCP-1)、基质金属蛋白酶-2(MMP-2)、基质金属蛋白酶-9(MMP-9)水平的影响,观察治疗安全性,随访3个月、6个月,统计两组患者复发率、自然妊娠率以及妊娠结局。结果治疗后,研究组患者治疗总好转率(88.89%,72/81)明显高于对照组(75.36%,52/69),差异有统计学意义(P<0.05);两组患者中医证候积分明显降低(P<0.05),研究组各积分明显低于对照组(P<0.05);两组患者MCP-1、MMP-2、MMP-9水平明显降低(P<0.05),研究组治疗后低于对照组(P<0.05);研究组不良反应发生率(8.64%,7/81)与对照组(15.94%,11/69)比较,差异无统计学意义(P>0.05),随访6个月,研究组复发率(6.17%,5/81)明显低于对照组(18.84%,13/69),自然妊娠率(58.02%,47/81)明显高于对照组(30.43%,21/69),差异有统计学意义(P<0.05);研究组足月分娩率、剖宫产率、宫外孕率与对照组比较,无明显统计学意义(P>0.05),自然流产率明显低于对照组(P<0.05),两组良好妊娠结局以及不良妊娠结局情况比较,差异有统计学意义(χ^(2)=4.61,P>0.05)。结论自拟方调经止痛丸治疗EMT效果显著,可明显缓解患者临床症状,调节血清标志物水平,降低患者远期复发率,提高自然妊娠率,改善妊娠结局。Objective To observe the effects and safety of Self-made Tiaojing Zhitong Pill(自拟调经止痛丸) in the treatment of endometriosis(EMT).Methods A total of 150 patients with EMT admitted to our hospital were enrolled in the study.They were divided into control group and study group according to the random principle.Sixty-nine patients in control group were given inhalation therapy of gestrinone orally and 81 patients in study group were given Self-made Tiaojing Zhitong Pill combined with inhalation therapy of gestrinone orally,and they were treated for 6 months.The effects of the two treatment methods on clinical efficacy,TCM syndromes scores(pain,menstrual blood clots,pelvic nodules,soreness and weakness of waist and knees) and serum markers[monocyte chemoattractant protein-1(MCP-1),matrix metalloproteinase-2(MMP-2),matrix metalloproteinase-9(MMP-9)] among EMT patients were observed.The treatment safety was observed,and the recurrence rate,natural pregnancy rate and pregnancy outcomes were counted in the two groups at 3 and 6 months of follow-up.Results After treatment,the total improvement rate of treatment in study group was significantly higher than that in control group[88.89%(72/81) vs 75.36%(52/69)](P<0.05).The TCM syndromes scores in the two groups were significantly decreased(P<0.05),and the scores in study group were significantly lower than those in control group(P<0.05).The levels of MCP-1,MMP-2 and MMP-9 were significantly decreased in the two groups(P<0.05),and the levels in study group were lower than those in control group after treatment(P<0.05).The incidence rate of adverse reactions in study group was not significantly different from that in control group[8.64%(7/81) vs 15.94%(11/69)](P>0.05).At 6 months of follow-up,the recurrence rate in study group was significantly lower than that in control group[6.17%(5/81) vs 18.84%(13/69)] while the natural pregnancy rate was significantly higher than that in control group[58.02%(47/81) vs 30.43%(21/69)](P<0.05).There were no significant differences

关 键 词：自拟方调经止痛丸 子宫内膜异位症 安全性 

分 类 号：R711.71[医药卫生—妇产科学]