基于“肾藏精”理论探讨何学红教授治疗慢性肾小球肾炎学术思想与临床研究  

Discussion on Professor HE Xuehong’s Academic Thought about Treating Chronic Glomerulonephritis and Clinical Research Based on the Theory of “Kidney Storing Essence”

作　　者：张世涛[1] 远方[1] 何学红[1] ZHANG Shitao;YUAN Fang;HE Xuehong(Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang 110032,Liaoning,China)

机构地区：[1]辽宁中医药大学附属医院,辽宁沈阳110032

出　　处：《辽宁中医药大学学报》2021年第3期43-46,共4页Journal of Liaoning University of Traditional Chinese Medicine

基　　金：国家重点基础研究发展计划(973计划)(2013CB532004);辽宁省自然科学基金(20170540607)。

摘　　要：目的基于"肾藏精"理论探讨何学红教授治疗慢性肾小球肾炎的学术思想与临床研究。方法以本院2018年5月—2020年5月收治的慢性肾小球肾炎患者94例为观察对象,随机分为观察组与对照组,各47例。两组均给予常规治疗,观察组在此基础上基于"肾藏精"理论联合滋肾露进行治疗,共治疗4周。比较2组患者肾功能及24 h尿蛋白表达含量、炎性因子水平、肾纤维化指标及临床疗效。结果 2组患者尿素氮(BUN)、肌酐(SCr)及24 h尿蛋白定量均较治疗前有所降低(P<0.05),观察组上述指标改善程度较对照组更显著(P<0.05);经治疗,2组患者白细胞介素-6(IL-6)和肿瘤坏死因子(TNF-α)水平均较治疗前降低,白细胞介素-10(IL-10)水平较治疗前升高(P<0.05),观察组患者上述炎性因子水平变化幅度较对照组更显著(P<0.05);经治疗,2组患者胱抑素C(CysC)、转化生长因子β1(TGF-β1)水平均较治疗前降低,纤维连接蛋白(FN)水平较治疗前升高(P<0.05),观察组患者上述肾纤维化指标变化幅度较对照组更显著(P<0.05);观察组临床总有效率优于对照组(93.62%/70.21%)(P<0.05)。结论何学红教授基于"肾藏精"理论所拟的滋肾露可起到健脾补肾、清利湿热的功效,在治疗慢性肾小球肾炎方面取得较好疗效,能够有效改善临床症状及肾功能,降低24 h尿蛋白定量,降低血清炎性因子水平,改善肾纤维化指标,值得临床应用。Objective The purpose of this paper was to discuss professor HE Xuehong’s academic thought about treating chronic glomerulonephritis based on the theory of"kidney storing essence"and to conduct a clinical research. Methods Collected the information of chronic glomerulonephritis patients admitted to our hospital from May 2018 to May 2020. 94 patients were randomly divided into two groups[(control group(group A)vs. treatment group(group B)]. 47 patients in the group A were treated with conventional Western medicine treatment(Schedule A). 47 patients in the group B were treated with Zishenlu(滋肾露)plus schedule A,the course of treatment all lasting 4 weeks. Renal function,24-hour urinary protein expression level,inflammatory factor level,level of renal fibrosis index and clinical efficacy were compared. Results After treatment,the results of the treatment group compared with the control group were as follows:The levels of BUN,SCr,CysC and 24 h urine protein quantification decreased in both groups(P<0.05),and the improvement degree of the above indexes in the group B was more significant(P<0.05). In both groups,the levels of IL-6 and TNF-αdecreased,and the levels of IL-10 increased(P<0.05). The changes of above inflammatory factors levels in the group B were more significant than those in the group A(P<0.05). In both groups,the levels of CysC and TGF-β1 decreased,and the levels of FN increased(P<0.05). The changes of above renal fibrosis indexes levels in group B were more significant than those in group A. Clinical total effective rate:The rate in group B(93.62%)was significantly higher than that in group A(70.21%)(P<0.05). It showed that the group B was better than the group A(P<0.05).Conclusion Zishenlu prepared by professor HE Xuehong based on the theory of"kidney storing essence"has the effects of tonifying spleen and kidney,eliminating dampness and heat,and has achieved good curative effect in treating chronic glomerulonephritis. It can effectively improve clinical symptoms and renal function,reduce the

关 键 词：肾藏精 慢性肾小球肾炎 水肿 炎性因子 肾纤维化 

分 类 号：R692.31[医药卫生—泌尿科学]