某院193例血流感染患者血液中分离出的葡萄球菌对不同抗菌药物的药敏结果分析  

Analysis in Drug Sensitivity of Staphylococcus Isolated from Blood of 193 Patients with Bloodstream Infection in a Hospital to Different Antimicrobial Agents

作　　者：朱京乐 冯婷婷[1] 赵卫峰[1] ZHU Jing-le;FENG Ting-ting;ZHAO Wei-feng(Department of Infectious Diseases,The No.1 Hospital Affiliated to Soochow University,Suzhou Jiangsu 215000,China)

机构地区：[1]苏州大学附属第一医院感染病科,江苏苏州215000

出　　处：《抗感染药学》2021年第3期326-330,共5页Anti-infection Pharmacy

摘　　要：目的:分析医院不同科室血流感染患者葡萄球菌的分布及其耐药性,为葡萄球菌血流感染患者临床治疗提供参考。方法:选取医院2019年1月—12月间各科室送检患者193例标本中分离出的血流感染葡萄球菌193株及其临床资料,分析其血流感染患者不同科室葡萄球菌的分布及其对抗菌药物的耐药情况,以及耐甲氧西林金黄色葡萄球菌(MRSA)、甲氧西林敏感的金黄色葡萄球菌(MSSA)的分离和耐药情况。结果:193株血流感染葡萄球菌中,金黄色葡萄球菌有41株(占21.24%),凝固酶阴性葡萄球菌有152株(占78.76%);药敏结果发现,金黄色葡萄球菌对青霉素、红霉素及克林霉素的耐药率分别为85.37%、51.22%和48.78%,而对万古霉素、替考拉宁、利奈唑胺等均全部敏感;凝固酶阴性葡萄球菌对青霉素的耐药率达98.68%,对红霉素的耐药率达84.87%,其对环丙沙星、左氧氟沙星、莫西沙星3种喹诺酮类药物的耐药率也高于70%,而对万古霉素、替考拉宁、替加环素全部敏感;绝大多数葡萄球菌对利奈唑胺敏感,而MRSA检出率及耐药率均较高。结论:医院临床葡萄球菌多重耐药较为严峻,且MRSA的检出率和耐药率均高于MSSA;临床应高度重视,并根据药敏结果及时调整用药方案。Objective:To analyze the distribution and drug resistance of Staphylococcus in patients with bloodstream infection in different departments of the hospital,so as to provide a reference for clinical treatment of patients with bloodstream infection caused by Staphylococcus.Methods:A total of 193 strains of Staphylococcus bloodstream infection isolated from patients in different departments of the hospital from January to December 2019 were selected and their clinical data were analyzed.The distribution of Staphylococcus in patients of different departments with bloodstream infection and their drug resistance to antibiotics,as well as the isolation and drug resistance of MRSA and MSSA were analyzed.Results:Among 193 strains of Staphylococcus bloodstream infection,41 strains of Staphylococcus aureus(21.24%)and 152 strains of Coagulase Negative Staphylococcus(78.76%);the drug resistance rates of Staphylococcus aureus to penicillin,erythromycin and clindamycin were 85.37%and 51.22%,respectively.The resistance rates of Coagulase negative Staphylococcus to penicillin was 98.68%,and to erythromycin was 84.87%.The resistance rates to ciprofloxacin,levofloxacin and moxifloxacin were higher than 70%.Most of Staphylococcus were sensitive to linezolid,but the detection rates and drug resistance rates of methicillin-resistant Staphylococcus aureus(MRSA)were high.Conclusion:The clinical multi drug resistance of Staphylococcus in hospital was severe,and the detection rates and drug resistance rates of MRSA were higher than MSSA.Clinical attention should be paid to it and drug regimen should be adjusted on time based on drug sensitivity results.

关 键 词：金黄色葡萄球菌 凝固酶阴性葡萄球菌 血流感染 耐药性 多重耐药 

分 类 号：R915[医药卫生—微生物与生化药学] R969.3[医药卫生—药学]