侧柏叶、何首乌复合提取物防脱发功效研究  

Study on the Anti-hair Loss Effects of the Compound Extract of Platycladus orientalis and Polygonum multiflorum

作　　者：马世宏[1] 单承莺[1] 聂韡[1] 束成杰 Ma Shihong;Shan Chengying;Nie Wei;Shu Chengjie(Nanjing Institute of Comprehensive Utilization of Wild Plants, Nanjing 211110,China)

机构地区：[1]南京野生植物综合利用研究院,江苏南京211110

出　　处：《中国野生植物资源》2021年第5期43-47,共5页Chinese Wild Plant Resources

摘　　要：制备侧柏叶、何首乌复合提取物,采用体外1,1-二苯基-2-三硝基苯肼(DPPH)自由基清除率实验、5α-还原酶抑制实验和小鼠动物模型对其进行防脱发功效研究。结果表明,该复合提取物在100 mg/mL的有效浓度下可有效清除DPPH,体外可显著抑制5α-还原酶活性,动物试验结果表明能明显改善小鼠雄激素源性脱发。该复合提取物具有防脱发功效,可用于防脱发个人护理用品的开发。The compound extract of Platycladus orientalis and Polygonum multiflorum was prepared,and the anti-hair loss effects were studied by 1,1-Diphenyl-2-picrylhydrazylradical2,2-Diphenyl-1-(2,4,6-trinitrophenyl)hydrazyl(DPPH)clearance test in vitro,5α-reductase inhibition test in vitro and mice experimental model.The results showed that the composite extract could effectively eliminate DPPH,and significantly inhibit 5α-reductase activity at an effective concentration of 100 mg/mL in vitro.The animal experiment result showed that it could significantly improve androgen-induced alopecia in mice.The compound extract has anti-hair loss effect and can be used in the development of anti-hair loss personal care products.

关 键 词：侧柏叶 何首乌 5Α-还原酶 雄激素源性脱发 

分 类 号：R282[医药卫生—中药学]