白细胞介素-6在酒精性肝病中的作用  

The Role of Interleukin-6 in Alcoholic Liver Disease

作　　者：崔玮 崔迪 CUI Wei;CUI Di(Human Science Laboratory,Department of Physical Education,Hunan University,Changsha 410000,China)

机构地区：[1]湖南大学体育学院人体科学实验室,长沙410000

出　　处：《中国生物化学与分子生物学报》2021年第4期467-474,共8页Chinese Journal of Biochemistry and Molecular Biology

基　　金：湖南省体育局体育科学学会重点项目(No.2018XH001);湖南省体育局体育科学学会一般项目(No.2020XH030)资助。

摘　　要：酒精性肝病(alcoholic liver disease,ALD)是由于长期过量饮酒导致肝的内部组织发生炎症损伤的慢性肝病。乙醇及其衍生物在代谢过程中直接或间接诱导引起的肝炎症反应可能是ALD发病的重要机制。然而,该过程内在的细胞分子机制尚不明确。最新研究发现,白细胞介素-6(interleukin-6,IL-6)对乙醇介导的肝细胞炎症反应具有双重作用,既参与了酒精损伤的炎症驱动过程,激活细胞凋亡的信号通路来刺激巨噬细胞和淋巴细胞合成急性反应蛋白加剧炎症反应,又能引起肝细胞再生,上调抗炎性细胞因子水平,发挥抗炎症功能来改善肝损伤程度。而运动应激可造成肌源性IL-6暂时性显著增加,改变肝的氧化-炎症状态,将机体保持在长期抗炎症的适应性状态中,并防治肝细胞炎症损伤。本文在加深对酒精性肝病炎症病理机制理解的同时,综述有关酒精性肝细胞炎症相关因子变化及IL-6调控途径。考虑临床利用IL-6联合炎性因子途径的靶向治疗,将有望成为一种可行性新颖的疗法,有利于实验室筛选炎症相关酒精性肝病干预药物,为酒精性肝疾病的预防与治疗提供新的靶点与思路。Alcoholic liver disease(ALD)is a chronic liver disease in which the internal liver tissues are inflammation damaged caused by long-term excessive drinking.Direct or indirect induction of hepatic inflammatory response by ethanol and its derivatives in the metabolic process may be an important mechanism of ALD,but the underlying cellular and molecular mechanisms of this process are still unclear.Recent study found that interleukin-6(IL-6)response to ethanol mediated inflammation of the liver cells with dual role.It is involved in an inflammatory process that drives alcohol damage,activate cell apoptosis signaling pathways to stimulate macrophage and lymphocyte acute reactive protein synthesis aggravate the inflammatory response,and can lead to liver cell regeneration,increase anti-inflammatory cytokine levels play anti-inflammatory function to improve the degree of liver injury,and exercise stress can cause muscle source sex IL-6 temporary increased significantly,change the liver oxidation-inflammatory state.Then the body is kept in the adaptive state of long-term anti-inflammation to prevent the inflammatory damage of liver cells.Based on deepening the understanding of ALD inflammation pathological mechanism at the same time,the review on alcoholic liver cell inflammation related factor change and the IL-6 regulation pathway,considering the clinical use of IL-6 joint inflammatory factor pathway of targeted therapy is expected to be a novel therapy,the feasibility for laboratory screening of inflammatory related ALD drug intervention,for the prevention of alcoholic liver disease and treatment to provide new targets and train of thought.

关 键 词：白细胞介素-6 酒精性肝病 炎症反应 信号转导和转录激活因子3 核转录因子-KB 

分 类 号：Q575.5[生物学—生物化学]