针刺轻度认知障碍患者太溪穴任务态功能磁共振成像研究  

Task Portion fMRI Study of Needling KI3 in Treatment of MCI

作　　者：曹丹娜[1,2] 李晓陵[2] 王丰[2] 李孟[1] 刘晓慧 姜晓旭[1] 姚春丽[1] 蔡丽娜 CAO Danna;LI Xiaoling;WANG Feng;LI Meng;LIU Xiaohui;JIANG Xiaoxu;YAO Chunli;CAI Lina(Heilongjiang University of Chinese Medicine, Harbin 150040, China;The First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin 150040, China)

机构地区：[1]黑龙江中医药大学,黑龙江哈尔滨150040 [2]黑龙江中医药大学附属第一医院,黑龙江哈尔滨150040

出　　处：《中医药信息》2021年第5期49-53,共5页Information on Traditional Chinese Medicine

基　　金：国家自然科学基金面上项目(81373714,81973930,82074537);黑龙江省自然科学基金项目(H2016081,LH2020H103);哈尔滨市科技创新人才优秀学科带头人基金项目(2016RAXYJ096);哈尔滨市科技创新人才专项资金项目(2017RAQXJ180)。

摘　　要：目的:基于任务态功能磁共振成像技术,通过观察轻度认知障碍(MCI)患者太溪穴针刺态脑神经元活动的改变,探讨针刺对认知相关脑区的神经调节机制。方法:选择轻度认知障碍患者16例,采用16 min任务态实验设计。使用3.0T磁共振扫描仪,首先采集8 min基线静息态数据,再采集8 min针刺太溪穴的针刺态数据。数据经后处理与一般线性模型分析,基于体素水平P=0.001(未校正)和cluster水平P<0.05(FWE校正),获得MCI患者针刺态脑内神经元活动改变的脑功能区。结果:针刺MCI患者右侧太溪穴正激活脑区为左侧眶部额下回(BA47)、右侧三角部额下回(BA45)、左侧岛盖部额下回(BA44)、右侧岛叶(BA13)、左侧颞上回(BA38)、右侧颞下回(BA20)、右侧小脑前叶、后叶、右侧丘脑。负激活脑区为左侧后扣带回(BA31)、左侧楔前叶(BA7)、右侧海马回。结论:针刺MCI患者太溪穴的即刻效应可直接影响认知活动相关脑区的神经元活动,调节病理性失衡的认知回路,可能是针灸对MCI治疗的潜在神经机制。Objective:To investigate the neural regulatory mechanism of acupuncture on cognitive related brain regions by observing the changes of neuronal activity of the patients with mild cognitive impairment(MCI)after needling Taixi(KI3)acupoint,based on task portion functional magnetic resonance imaging(fMRI).Methods:16 patients with MCI were enrolled in this study by using 16-minute task portion experiment design.The 8-minute baseline resting state data were collected first,and then another 8-minute state data of needling KI3 were collected by using 3.0T magnetic resonance scanner.The data were analyzed by post-processing and general linear model.Based on the voxel level of P=0.001(uncorrected)and the cluster level of P<0.05(FWE correction),the changed functional areas of brain neurons were obtained in MCI patients with acupuncture state.Results:The positive activation areas of needling right KI3 in MCI patients were left inferior frontal gyrus(BA47),right inferior frontal gyrus(BA45),inferior frontal gyrus(BA44),right insular(BA13),left superior temporal gyrus(BA38),right inferior temporal gyrus(BA20),right anterior cerebellar lobe,posterior lobe and right thalamus.The negative activation areas were left posterior cingulate gyrus(BA31),left precuneus lobe(BA7)and right hippocampal gyrus.Conclusion:The immediate effect of needling KI3 in MCI patients can directly affect the neuronal activities in the brain regions related to cognitive activities,and it can regulate the cognitive circuit of pathological imbalance,which may be the potential neural mechanism of acupuncture in treating MCI.

关 键 词：针刺 任务态 功能磁共振成像 轻度认知障碍 太溪穴 

分 类 号：R246.6[医药卫生—针灸推拿学]