黄酮类衍生物抗肿瘤作用研究进展  

Research progress on the antitumor effect of flavonoid derivatives

作　　者：李鑫萍 于渼璇 况婷瑞 延玺[1] 李春颖[2] 郝海军[3] LI Xin-ping;YU Mei-xuan;KUANG Ting-rui;YAN Xi;LI Chun-ying;HAO Hai-jun(College of Chemistry,Beijing Normal University,Beijing 100875,China;Department of Obstetrics and Gynecology,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences,Beijing 100730,China;Department of Organic Chemistry,College of Science,Beijing University of Chemical Technology,Beijing 100029,China)

机构地区：[1]北京师范大学化学学院,北京100875 [2]中国医学科学院北京协和医院妇产科,北京100730 [3]北京化工大学理学院有机化学系,北京100029

出　　处：《药学学报》2021年第4期913-923,共11页Acta Pharmaceutica Sinica

基　　金：国家科技重大项目(2014zx09507007-003)。

摘　　要：恶性肿瘤是严重危害人类生命健康的疾病,一直是科研工作者的研究重点之一。天然黄酮及其衍生物具有多种生理活性,尤其在抗肿瘤生长方面具有独特生物活性,既可以通过参与干扰肿瘤细胞周期,改变肿瘤细胞线粒体膜电位,促进肿瘤细胞的凋亡,也可以通过提高人体免疫力,减小肿瘤细胞的免疫逃逸,阻止肿瘤转移。在人体内,它们调整生物信号转导,导致促凋亡蛋白表达上调,通过调控血管上皮细胞的生长,阻断肿瘤组织中血管的生成,达到抑制实体肿瘤生长的目的。此类化合物在对多种肿瘤的研究过程中均表现药理活性,有望开发为新型抗肿瘤药物。本文总结了近年来黄酮类化合物在抗肿瘤作用机制及药效学方面的进展,旨在为相关科研工作者提供一定的参考与帮助。Malignant tumors seriously endanger human life and health,and their treatment has always been a research focus of scientists all over the world.Natural flavonoids and their derivatives have a variety of biological activities,especially regarding antitumor growth,with unique biological activities.They can interfere with the growth cycle of tumor cells,change the mitochondrial membrane potential,promote apoptosis,and can reduce the immune escape of tumor cells and prevent tumor metastasis by improving human immunity.In the human body,they regulate the biological signal transduction,leading to the up-regulation of pro-apoptotic protein expression.They inhibit the growth of solid tumors by regulating the growth of vascular epithelial cells and blocking the formation of blood vessels in tumor tissue.Recent studies have shown that these compounds can play an important role in the treatment of various human tumors and are expected to be developed into new antitumor drugs.This review summarizes the recent research results on the antitumor mechanism of flavonoids and their ability to inhibit tumor growth.

关 键 词：黄酮类化合物 癌症 抗肿瘤 天然植物 作用机制 

分 类 号：R979.1[医药卫生—药品]