基于相关实验室指标及病理指数探讨狼疮性肾炎微观血瘀证及非血瘀证的差异  

Difference of Micro-blood Stasis and Non-blood Stasis Syndrome of Lupus Nephritis Based on Relevant Laboratory and Pathological Indexes

作　　者：钱飞婷 张绍杰 陈洪宇[3] 曾佳丽[3] 王梦琦 QIAN Feiting;ZHANG Shaojie;CHEN Hongyu;ZENG Jiali;WANG Mengqi(Department of Nephrology,Shaoxing Traditional Chinese Medicine Hospital,Shaoxing 312000,Zhejiang,China;Department of Nephrology,Hangzhou Dingqiao Hospital,Hangzhou 310021,Zhejiang,China;Department of Nephrology,Hangzhou Chinese Medicine Hospital,Hangzhou 310007,Zhejiang,China;Department of Traditional Chinese Medicine,Shanghai Fengcheng Hospital,Shanghai 201400,China)

机构地区：[1]绍兴市中医院肾病科,浙江绍兴312000 [2]杭州市丁桥医院肾内科,浙江杭州310021 [3]杭州市中医院肾内科,浙江杭州310007 [4]上海市奉城医院中医科,上海201400

出　　处：《辽宁中医杂志》2021年第3期74-77,共4页Liaoning Journal of Traditional Chinese Medicine

基　　金：浙江省中医药科技计划青年人才基金(2018ZQ043);国家自然科学基金(81973760)。

摘　　要：目的探讨狼疮性肾炎(LN)微观血瘀非血瘀证之间相关实验室指标及病理指数之间的差异。方法回顾性研究收集确诊为LN患者104例,分为微观血瘀证组及微观非血瘀证组,比较两组之间血常规、尿常规、肾功能、肝功能相关实验室指标、凝血功能及相关病理指数的差异。结果104例患者中微观血瘀证组73例,微观非血瘀证组31例,微观血瘀证组患者尿素氮(BUN)、肌酐(SCR)、尿酸(UA)、胱抑素C(CYS-C)、肾脏病理活动指数(AI)、肾脏病理慢性化指数(CI)高于微观非血瘀证组(P<0.05),微观血瘀证组患者的红细胞(RBC)、血红蛋白(HGB)、内生肌酐清除率(CCR)低于微观非血瘀证组(P<0.05)。两组患者超敏C反应蛋白(CRP)、白细胞(WBC)、血小板(PLT);隐血(BLD)、尿蛋白(PRO)、谷丙转氨酶(ALT)、谷草转氨酶(AST)、白蛋白(ALB)、胆固醇(TCH)、甘油三酯(TG)、低密度脂蛋白(LDL)、凝血酶原时间(PT)、部分凝血活酶时间(APTT)、凝血酶时间(TT)、纤维蛋白原(FIB)、D-二聚体(DD)等指标比较差异无统计学意义(P>0.05)。结论从实验室指标及病理指标可以看出LN微观血瘀证患者与微观非血瘀证患者的相关实验室指标及病理指标存在差异,所以临床上可以借助上述指标来辅助辨证是否为血瘀证,LN血瘀证患者应该在治疗主症的基础上注重活血化瘀,会起到更好的效果。Objective To explore the differences of laboratory and pathological indexes between microcosmic blood stasis and non-blood stasis syndrome in lupus nephritis(LN).Methods A retrospective study was conducted on 104 patients with LN.They were divided into two groups:microcosmic blood stasis syndrome group and microcosmic non-blood stasis syndrome group.The differences of blood routine,urine routine,coagulation function,24-hour urinary protein quantification,endogenous creatinine clearance rate(CCR),serum cystatin(CYS-C),liver function and renal function between the two groups were compared.Results Among 104 patients,73 were in micro blood stasis syndrome group,31 were in micro non-blood stasis syndrome group.SCR,BUN,UA,CYS-C,AI and CI in micro blood stasis syndrome group were higher than those in micro non-blood stasis syndrome group(P<0.05),while RBC,HGB and CCR in micro blood stasis syndrome group were lower than those in micro non-blood stasis syndrome group(P<0.05).There was no significant difference in CRP,WBC,PLT,BLD,PRO,NAG,24-hour urinary protein quantification,ALT,AST,ALB,TCH,TG,LDL,PT,APTT,TT,FIB,DD between the two groups(P>0.05).Conclusion From the laboratory and pathological indicators,we can see that there are differences in laboratory and pathological indicators between LN patients with microcosmic blood stasis syndrome and those with microcosmic non-blood stasis syndrome.Therefore,the above indicators can be used to assist the clinical differentiation of blood stasis syndrome.LN patients with blood stasis syndrome should pay attention to promoting blood circulation and removing blood stasis on the basis of the treatment of the main symptoms,which will play a better role.

关 键 词：狼疮性肾炎 微观血瘀证 实验室指标 病理指数 

分 类 号：R593.242[医药卫生—内科学]