生物基高分子型止血材料和伤口敷料  

Bio-Based Polymeric Hemostatic Material and Wound Dressing

作　　者：林建云 罗时荷[1] 杨崇岭[2] 肖颖 杨丽庭[1] 汪朝阳[1] Jianyun Lin;Shihe Luo;Chongling Yang;Ying Xiao;Liting Yang;Zhaoyang Wang(School of Chemistry,South China Normal University,Guangzhou 510006,China;Guangdong Industry Polytechnic,Guangzhou 510300,China)

机构地区：[1]华南师范大学化学学院教育部环境理论化学重点实验室广州市生物医药分析化学重点实验室,广州510006 [2]广东轻工职业技术学院,广州510300

出　　处：《化学进展》2021年第4期581-595,共15页Progress in Chemistry

基　　金：国家自然科学基金项目(No.20772035);广东省科技计划项目(No.2017A010103016);广东省自然科学基金项目(No.2021A1515012342);广东省功能分子工程重点实验室资助课题(No.2017kf01);广州市科技计划项目(No.202002030362,201607010301)资助。

摘　　要：伤口的快速止血和愈合对人类的生命保障和身体健康有十分重要的影响,使得伤口护理材料的研究备受关注。其中,从动植物中提取或由生物基单体合成而得的生物基高分子材料,因具有良好的物理性能、生物活性、生物相容性、生物降解性和生物可吸收性等优点,被人们通过物理或化学方法,进行改性或药物负载,制成具有止血、杀菌、保护和促进伤口愈合等功能的止血材料和伤口敷料。本文从化学组成、制备方法、材料结构、评价方法和生物活性等多角度综述了近年来(特别是近5年来)聚乳酸、壳聚糖、海藻酸钠、透明质酸、蛋白质和聚磷酸盐等常见的生物基高分子在止血材料和伤口敷料方面的国内外研究进展,并分析对比了国内外研究水平。展望未来的研究和发展方向,在原料的种类拓宽、材料的多功能化和仿生化等方面仍待努力。The rapid hemostasis and healing of wounds have a very important effect on human life security and physical health.During the treatment process of wounds,careful,targeted,and effective treatment is required to prevent infection and accelerate tissue regeneration.Thus,the research on wound care materials attracted much attention.Among them,bio-based polymer materials extracted from animals and plants or synthesized from bio-based monomers,having the advantages of good physical properties,biological activity,biocompatibility,biodegradability and bioabsorbability,have been modified or drug-loaded by physical or chemical methods to produce hemostatic materials and wound dressings with functions of hemostasis,sterilization,protection and promotion of wound healing.Herein,we review the progress of domestic and foreign research on hemostatic materials and wound dressings based on common bio-based polymers,such as polylactic acid,chitosan,sodium alginate,hyaluronic acid,protein and polyphosphate in recent years from multiple angles of chemical composition,synthetic route,preparation method,material structure,evaluation model and biological activity.And the research level at home and abroad on these hemostatic materials from bio-sourced and renewable natural resources is also analyzed and compared.Predictably,the main research directions will still be further broadening the types of raw materials as well as making multifunctional and biomimetic materials.

关 键 词：生物基高分子 止血材料 伤口敷料 聚乳酸 多糖 多肽 

分 类 号：O633.14[理学—高分子化学] O636.1[理学—化学]