绒毛膜血管病对新生儿的影响:450例临床分析  

Influence of placental pathological chorangiosis on neonates:an analysis of 450 cases

作　　者：吴琳琳[1] 林新祝 郑直 何泽生 WU Lin-Lin;LIN Xin-Zhu;ZHENG Zhi;HE Ze-Sheng(Department of Neonatology,Women and Children's Hospital,School of Medicine,Xiamen Key Laboratory of Perinatal Infection,Xiamen,Fujian 361001,China)

机构地区：[1]厦门大学附属妇女儿童医院/厦门市妇幼保健院新生儿科,厦门市围产-新生儿感染重点实验室,福建厦门361001 [2]厦门大学附属妇女儿童医院/厦门市妇幼保健院病理科,福建厦门361001

出　　处：《中国当代儿科杂志》2021年第5期494-498,共5页Chinese Journal of Contemporary Pediatrics

基　　金：2017年厦门市科技重大专项(3502Z2017006)。

摘　　要：目的研究母亲胎盘病理绒毛膜血管病对新生儿病死率和并发症发生率的影响。方法回顾性分析2016年7月至2020年2月厦门市妇幼保健院新生儿科生后3 d内住院的患儿,根据母亲胎盘病理是否提示绒毛膜血管病分为观察组和对照组,各450例。分析两组患儿的一般情况、母亲妊娠期合并症、新生儿病死率和新生儿并发症的发生率。结果观察组剖宫产率高于对照组(P<0.05),观察组母亲妊娠高血压发生率高于对照组(P<0.05)。与对照组相比,观察组患儿先天结构畸形、小于胎龄儿、低Apgar评分发生率更高(P<0.05);观察组患儿病死率、脑损伤发生率、早产儿视网膜病及宫外生长发育迟缓的发生率均更高(P<0.05)。结论母亲胎盘病理绒毛膜血管病的新生儿病死率更高,并发症发生率更高,需提高对绒毛膜血管病的认识,尽早干预,减少并发症,改善预后。Objective To study the influence of placental pathological chorangiosis in the mother on the mortality of neonates and the incidence rate of complications.Methods A retrospective analysis was performed for the neonates who were hospitalized within 3 days after birth in the Department of Neonatology,Xiamen Maternal and Child Health Hospital,from July 2016 to February 2020.According to whether the placental pathology showed chorangiosis,the neonates were divided into an observation group and a control group(n=450 each).The two groups were analyzed in terms of general status,maternal comorbidities during pregnancy,neonatal mortality,and incidence rate of complications in neonates.Results Compared with the control group,the observation group had a significantly higher cesarean section rate(P<0.05)and a significantly higher incidence rate of maternal gestational hypertension(P<0.05).The observation group had significantly higher incidence rates of congenital malformation,small-for-gestational-age birth,and low Apgar score than the control group(P<0.05).The observation group also had significantly higher mortality rate and incidence rates of brain injury,retinopathy of prematurity,and extrauterine growth retardation(P<0.05).Conclusions Neonates born to mothers with placental pathological chorangiosis tend to have a higher morbidity rate and incidence rate of complications.It is important to improve the understanding of chorangiosis and provide intervention as soon as possible,in order to reduce complications and improve prognosis.

关 键 词：绒毛膜血管病 胎盘病理 病死率 并发症 新生儿 

分 类 号：R722.1[医药卫生—儿科]