纳米材料在骨髓炎治疗中的应用研究进展  

Research progress of nanomaterials in osteomyelitis treatment

作　　者：王珮琳 林浩东 WANG Peilin;LIN Haodong(Department of Orthopaedics,Shanghai General Hospital,Shanghai,200080,P.R.China)

机构地区：[1]上海市第一人民医院骨科,上海200080

出　　处：《中国修复重建外科杂志》2021年第5期648-655,共8页Chinese Journal of Reparative and Reconstructive Surgery

摘　　要：目的对纳米材料在骨髓炎治疗中的相关应用研究进展进行综述,为骨髓炎的研究及临床治疗提供新思路。方法查阅近年国内外应用纳米材料治疗骨髓炎的相关文献,并进行分析和总结。结果目前,手术治疗和抗生素应用是骨髓炎的主要治疗方案,但存在抗生素耐药、骨缺损残留、局部药物有效浓度较低等诸多缺陷。应用纳米材料则能针对性地弥补上述缺陷。近年来,在骨髓炎治疗中纳米材料主要通过填充骨缺损、建立局部载药缓释系统以及自身抗菌等特性发挥作用。结论充分研究纳米材料相关特性,并选择有益材料制作载药系统或替代药物,为骨髓炎的治疗提供了全新思路及重要研究方向。Objective To review the related studies on the application of nanomaterials in the treatment of osteomyelitis, and to provide new ideas for the research and clinical treatment of osteomyelitis. Methods The literature about the treatment of osteomyelitis with nanomaterials at home and abroad in recent years was reviewed and analyzed.Results At present, surgical treatment and antibiotic application are the main treatment options for osteomyelitis. But there are many defects such as antibiotic resistance, residual bone defect, and low effective concentration of local drugs.The application of nanomaterials can make up for the above defects. In recent years, nanomaterials play an important role in the treatment of osteomyelitis by filling bone defects, establishing local drug delivery system, and self-antibacterial properties. Conclusion It will provide a new idea and an important research direction for the treatment of osteomyelitis to fully study the related characteristics of nanomaterials and select beneficial materials to make drug delivery system or substitute drugs.

关 键 词：骨髓炎 纳米材料 骨缺损 局部载药缓释系统 成骨分化 破骨分化 抗菌 

分 类 号：R681.2[医药卫生—骨科学]