槐杞黄颗粒对急性淋巴细胞白血病儿童维持期细胞免疫功能及重症感染的影响  

Effect of Huaiqihuang Granule (槐杞黄颗粒) on Cellular Immune Function and Severe Infection in Children with Acute Lymphoblastic Leukemia at Maintenance Stage

作　　者：安娜[1] 张古英[1] 刘艳辉[1] 梁玉丽[1] 李瑞宏[1] 丁翔宇[1] AN Na;ZHANG Gu-ying;LIU Yan-hui;LIANG Yu-li;LI Rui-hong;DING Xiang-yu(Children's Hospital of Hebei Province,Shijiazhuang Hebei 050031,China)

机构地区：[1]河北省儿童医院,河北石家庄050031

出　　处：《中医药导报》2021年第4期58-61,共4页Guiding Journal of Traditional Chinese Medicine and Pharmacy

基　　金：河北省2018年度医学科学研究重点课题(20180627)。

摘　　要：目的:研究槐杞黄颗粒对急性淋巴细胞白血病儿童维持期细胞免疫功能的影响。方法:收集2018年6月至2019年12月我院急性淋巴细胞白血病维持期患儿共60例,按照随机数字表法,随机分为治疗组30例、对照组30例。两组均按照维持化疗方案化疗,治疗组患儿在化疗基础上服用6个月槐杞黄颗粒。另外收集同期进行健康体检的儿童30人作为正常组。观察急性淋巴细胞白血病儿童维持阶段细胞免疫功能情况,比较维持治疗前后治疗组与对照组患儿细胞免疫功能变化,统计维持阶段治疗组与对照组患儿重症感染的发生情况。结果:急性淋巴细胞白血病儿童维持期T细胞亚群CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)低于正常组,CD8^(+)高于正常组,差异均有统计学意义(P<0.05)。维持治疗前后治疗组和对照组不同时间点CD3^(+)、CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+)比较,差异有统计学意义(P<0.01),两组CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)均呈上升趋势,CD8^(+)均呈下降趋势。治疗组患儿CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)显著高于对照组(P<0.01)。维持阶段治疗组患儿重症感染发生率为20.00%(6/30),显著低于对照组的46.77%(14/30)。结论:槐杞黄颗粒可改善急性淋巴细胞白血病儿童维持期的细胞免疫功能,减少重症感染发生率。Objective: To observe the effect of Huaiqihuang Granules on cellular immunity in maintenance stage of children with acute lymphoblastic leukemia. Methods: Totally 60 children with acute lymphoblastic leukemia in maintenance period in our hospital from June 2018 to December 2019 were randomly divided into treatment group(30 cases) and control group(30 cases) according to random number table method. The control group was given maintenance chemotherapy. The treatment group was given Huaiqihuang Granules for six months combined with the maintenance chemotherapy. And 30 children who underwent physical examination during the same period were collected as normal group. The cellular immunity of children with acute lymphoblastic leukemia at maintenance stage was observed. The changes of cellular immunity were observed before and after maintenance treatment in treatment and control groups. The incidence of severe infections was analyzed at the maintenance stage in the treatment and control groups. Results: Children with acute lymphoblastic leukemia in maintenance phase showed lower T lymphocyte subsets(CD3^(+),CD4^(+)and CD4^(+)/CD8^(+)) than normal group, while higher CD8^(+)than normal group, and the difference was statistically significant(P<0.05). There were significant differences in CD3^(+), CD4^(+), CD8^(+)and CD4^(+)/CD8^(+)in treatment and control groups at different time points before and after maintenance treatment(P<0.01). The CD3^(+), CD4^(+)and CD4^(+)/CD8^(+)showed an upward trend in treatment and control groups, while CD8^(+)showed a downward trend. The treatment group showed higher CD3^(+), CD4^(+)and CD4^(+)/CD8^(+)than control group(P<0.01). The incidence of severe infection in the maintenance phase was 20.00%(6/30) in treatment group and 46.77%(14/30) in control group. The treatment group showed lower incidence than control group. Conclusion: Huaiqihuang Granules can improve the cellular immunity and reduce the incidence of severe infections in maintenance phase of children with acute lymphoblastic leuk

关 键 词：急性淋巴细胞白血病 维持治疗 槐杞黄颗粒 细胞免疫 重症感染 儿童 

分 类 号：R273[医药卫生—中西医结合]