血液病患者发生急性输血不良反应的临床表现及输血效果分析  

Clinical features and transfusion effectiveness of patients with hematological diseases underwent acute transfusion reactions

作　　者：王莉[1] 邹玉 陈文珠 魏曾珍[1] 黄春妍[1] 秦莉[1] 谭斌[1] WANG Li;ZOU Yu;CHEN Wenzhu;WEI Zengzhen;HUANG Chunyan;QIN Li;TAN Bin(Department of Transfusion Medicine,Sichuan University West China Hospital,Chengdu 610041,China;Department of Transfusion Medi­cine,The First People's Hospital of Longquanyi District)

机构地区：[1]四川大学华西医院输血科,四川成都610041 [2]成都市龙泉驿区第一人民医院输血科

出　　处：《中国输血杂志》2021年第4期354-358,共5页Chinese Journal of Blood Transfusion

摘　　要：目的分析急性输血不良反应的真实发病率及临床特点,并探讨其与输血效果的相关性。方法现场观察本院血液科2018年3月16日~2019年3月16日期间输血患者的输血过程并进行追踪,记录患者的生命体征及临床表现、收集临床资料及相关实验室检查结果,统计分析急性输血不良反应的发病率、临床特点及其与输血效果的相关性。结果本研究总共观察到2 500例次输血过程,其中138名患者共发生242例急性输血不良反应。急性输血不良反应的发病率为9.68%(95%置信区间,8.52%~10.94%),且在输注血小板时发病率最高。大多数急性输血不良反应的临床表现轻微,未发生致命性事件。在血小板和红细胞输注中急性输血不良反应和输血疗效之间没有发现统计学差异(P>0.05)。结论本研究所观察到的急性输血不良反应均未导致严重后果且对输血效果没有影响,其呈现出的特征可为临床提供一定参考。Objective To demonstrate the real incidence and clinical features of acute transfusion reactions(ATRs) and analyze its association with transfusion effectiveness. Methods The blood transfusion process of patients in the Hematology Department in our hospital from March 16, 2018 to March 16, 2019 was observed and followed up. The vital signs and clinical features were recorded, the clinical data and relevant laboratory examination results were collected, and the correlation between ATRs, clinical features and transfusion effectiveness was statistically analyzed. Results A total of 2500 transfusions were observed in the Hematology Department, out of which 138 patients developed 242 ATRs. The overall incidence of ATRs was 9.68%(95% CI, 8.52%~10.94%) and the incidence of ATRs during platelets transfusion was the highest. The clinical features of most ATRs were mild and no fatal consequences occurred. No significant difference was found in the association between transfusion effectiveness with ATRs in platelets and red blood cells transfusion(P>0.05). Conclusion None of the ATRs observed in this study resulted in serious consequences or had effect on the transfusion effectiveness. The characteristics presented in these reactions may provide certain references for clinical practice.

关 键 词：急性输血不良反应 临床表现 输血效果 

分 类 号：R457.1[医药卫生—治疗学]