左氧氟沙星诱导急性溶血性贫血的诊治——附1例报告  

Levofloxacin-induced acute hemolytic anemia: A clinical case report

作　　者：唐聪海 林达义 林艺璇 胡晓明 甘玮玮 原敏 TANG Conghai;LIN Dayi;LIN Yixuan;HU Xiaoming;GAN Weiwei;YUAN Min(Department of Transfusion,Zhangzhou Affiliated Hospital of Fujian Medical University,Zhangzhou 363000,China;Department of Hematology,Zhangzhou Affiliated Hospital of Fujian Medical University,Zhangzhou 363000,China)

机构地区：[1]福建医科大学附属漳州市医院输血科,福建漳州363000 [2]福建医科大学附属漳州市医院血液科,福建漳州363000

出　　处：《中国输血杂志》2021年第4期392-395,共4页Chinese Journal of Blood Transfusion

摘　　要：目的探讨左氧氟沙星诱导急性溶血性贫血危象患者临床特征及其治疗。方法通过微柱凝胶法检测左氧氟沙星抗体,并经Naranjo药物不良反应概率表进行评分。通过全血置换和血浆置换对左氧氟沙星诱导急性溶血贫血进行抢救治疗。结果患者体内检测出左氧氟沙星抗体,Naranjo药物不良反应概率表评分为7分,为左氧氟沙星诱导的急性溶血症。经全血置换和血浆置换后,患者临床症状和体征迅速改善。辅以免疫球蛋白和激素治疗,患者在治疗后的d 10出院。结论左氧氟沙星可诱导急性溶血性贫血危象,全血置换和血浆置换是有效的抢救方法。Objective To study the clinical characteristics and treatment of patients with acute hemolytic anemia crisis induced by levofloxacin. Methods The levofloxacin antibody was detected by the microcolumn gel method and scored by the Naranjo Adverse Drug Reaction Probability Scale(APS). Patients suffered from acute hemolysis anemia induced by levofloxacin was rescued by whole blood exchange(WBE) and therapeutic plasma exchange(TPE).Results The patient was diagnosed as acute hemolysis induced by levofloxacin as levofloxacin antibody was yielded, and 7 points scored by the Naranjo APS. After WBE and TPE treatment, the patient′s clinical symptoms and signs improved rapidly. Supplemented with immunoglobulin and hormone therapy, the patient was discharged on d 10 after treatment. Conclusion Levofloxacin can induce acute hemolytic anemia crisis, and WBE and TPR are effective rescue methods.

关 键 词：全血置换 血浆置换 左氧氟沙星抗体 溶血性贫血 

分 类 号：R457.1[医药卫生—治疗学]