新型冠状病毒突变体D614G研究进展  

Research progress of SARS-CoV-2 D614G variant

作　　者：路琼 黄维金[1] 王佑春[1] LU Qiong;HUANG Wei-jin;WANG You-chun(National Institutes for Food and Drug Control,Key Laboratory of National Health Commission of the People’s Republic of China for Research on Quality and Standardization of Biotech Products,Key Laboratory of Biological Product Quality Research and Evaluation of State Drug Administration,Beijing 102629,China)

机构地区：[1]中国食品药品检定研究院艾滋病性病病毒疫苗室,国家卫生健康委员会生物技术产品检定方法与标准化重点实验室,国家药品监督管理局生物制品质量研究与评价重点实验室,北京102629

出　　处：《微生物学免疫学进展》2021年第2期73-77,共5页Progress In Microbiology and Immunology

基　　金：2020年度国家自然科学基金面上项目(3207040633)。

摘　　要：新型冠状病毒的变异,尤其是S蛋白的突变,成为现在关注的焦点,其中S蛋白的D614G的突变株迅速成为全球流行株,有研究显示其增强了复制力和感染力。现就D614G突变株引起的生物学改变和潜在分子机制等研究作一概述。Objective The major mutations detected in the SARS-CoV-2 viral envelope spike(S) protein have become the focus of attention now. Among them, the D614 G variant of S protein has rapidly become dominant during the COVID-19 pandemic worldwide, and some studies have shown its ability to enhance replication and infectivity. This paper summarizes the research progress of biological changes induced by the D614 G variant and its underlying mechanism.

关 键 词：新型冠状病毒肺炎 严重急性呼吸道综合征冠状病毒2型 变异 

分 类 号：R392[医药卫生—免疫学]