上海市长宁区老年糖尿病患者结核潜伏感染现况和预防性治疗态度  

Latent tuberculosis infection and preventive treatment attitude among elderly diabetic patients in Changning District of Shanghai

作　　者：张霞[1] 汤泓[1] ZHANG Xia;TANG Hong(Shanghai Changning Center for Disease Control and Prevention,Shanghai 200051,China)

机构地区：[1]上海市长宁区疾病预防控制中心,上海200051

出　　处：《中国热带医学》2021年第5期408-412,共5页China Tropical Medicine

基　　金：国家科技十三五重大专项(No.2018ZX10715012);长宁区科学技术委员会项目(No.CNKW2020Y38)。

摘　　要：目的了解上海市长宁区老年糖尿病患者结核病潜伏感染现况和结核潜伏感染者预防性治疗意愿,为调整长宁区肺结核高危人群结核病筛查策略和模式提供基础数据。方法抽取2019年9月—12月参加社区老年体检中60~79岁老年糖尿病患者,采用γ-干扰素释放试验检测结核菌感染情况,并对研究对象进行基本信息、健康状况、生活行为相关因素、体格检查结果、糖尿病诊疗及病程信息、血糖控制情况、结核病核心知识和LTBI知识知晓情况和预防性治疗态度问卷调查。用SPSS 22.0软件进行数据分析,组间差异的比较采用χ2检验,采用Logistic回归分析相关影响因素,以P<0.05为差异有统计学意义。结果老年糖尿病患者结核潜伏感染率为17.21%,有高血压史的人比无高血压史的人感染风险低(OR=0.557;95%CI:0.328~0.947);结核潜伏感染者对预防性服药治疗的接受率为60.81%。结论长宁区老年糖尿病患者结核潜伏感染率与国内其他研究报道相比处于较低水平,老年糖尿病患者中的结核潜伏感染者对预防性服药治疗的接受意愿较低。知晓结核病和结核潜伏感染相关知识,对接受预防性服药治疗起到积极作用。Objective To investigate the status of latent tuberculosis infection in elderly patients with diabetes mellitus in Changning District and their willingness of preventive treatment,and we provide basic data for the adjustment of tuberculosis screening strategy and mode in high-risk groups of tuberculosis in Changning District.Methods 60-79 years old patients with diabetes who participated in community physical examination from September to December in 2019 were selected.γ-interferon release test was used to detect tuberculosis infection,and the sampled population was surveyed on the basic information,health status,life behavior related factors,physical examination results,diabetes diagnosis and treatment and course of disease information,blood glucose control,tuberculosis core knowledge and LTBI knowledge awareness and preventive treatment attitude.SPSS 22.0 software was used to analyze the data.The rate comparison and multi-factor analysis were performed byχ2test and Logistic regression.P<0.05 was statistically significant difference.ResultsThe latent infection rate of tuberculosis(LTBI) in elderly diabetic patients was 17.21%,patients with a history of hypertension had a lower risk of infection than people without a history of hypertension (OR=0.557;95%CI:0.328-0.947);the acceptance rate of preventive treatment in patients with LTBI was 60.81%.Conclusion The LTBI rate in elderly patients with diabetes mellitus in Changning District is lower than that of other domestic research reported.The patients with LTBI have a lower willingness to take preventive treatment.Knowing the relevant knowledge of tuberculosis and latent infection of tuberculosis plays a positive role in receiving preventive treatment.

关 键 词：结核 潜伏感染 预防性治疗 接受度 

分 类 号：R52[医药卫生—内科学]