播散型组织胞浆菌病研究进展  

Advances in disseminated histoplasmosis

作　　者：王牛牛 郑建铭 刘丽光 WANG Niuniu;ZHENG Jianming;LIU Liguang(Infection department in Huashan hospital of Fudan University,Shanghai 200032,China;Infection department in Suzhou hospital affiliated of Anhui Medical university,Suzhou 234000,Anhui Province,China;Respiratory department in the 4th affiliated hospital of Anhui Medical university,Hefei 230012,Anhui Province,China)

机构地区：[1]复旦大学附属华山医院感染科,上海200032 [2]安徽医科大学附属宿州医院感染科,宿州234000 [3]安徽医科大学附属第四医院呼吸科,合肥230012

出　　处：《微生物与感染》2020年第6期429-434,共6页Journal of Microbes and Infections

摘　　要：组织胞浆菌病是由组织胞浆菌引起的深部真菌疾病。播散型组织胞浆菌病为所有临床分型中最为凶险的类型,其特点为起病急、发展快、死亡率高,诊断及治疗也颇为棘手。该病既往被认为是一种地方流行性疾病,多见于美国中西部等西半球地区,我国少见且多为输入性病例。但现阶段我国本土病例也屡有报道,故本文在复习相关文献基础上总结了播散型组织胞浆菌病的流行病学现状、易感人群、临床表现、诊断方法及治疗进展,以飨读者。Histoplasmosis is a class of fungal disease mainly caused by Histoplasma capsulatum.Most of the immunocompetent people infected with Histoplasma capsulatum were self-limited and had few clinical symptoms.However,those with immunodeficiency,organ transplants and a history of travel in epidemic areas may suffer from disseminated histoplasmosis characterized by urgent onset,rapid development,and high mortality.Histoplasmosis was once considered to be an epidemic mycosis in the western hemisphere.Although it was regarded as a rare and imported infection in China,indigenous cases have been reported recently.To prevent misdiagnosis of the disease,epidemiological status,susceptible population,clinical manifestations,diagnostic methods and treatment progresses of disseminated histoplasmosis are reviewed in this paper.

关 键 词：播散型组织胞浆菌病 组织胞浆菌 诊断 治疗 

分 类 号：R379.9[医药卫生—病原生物学] R519.8[医药卫生—基础医学]