成年猕猴C_(0)-T_(1)全颈椎有限元模型的建立及有效性验证  

Establishment and validation of C_(0)-T_(1) finite element model of cervical vertebrae in adult rhesus monkeys

作　　者：王星 徐雪彬 张少杰 郑秉武 杨喜 王超群 栗平[5] 马渊 李琨 陈杰 李筱贺 史君 李志军 Wang Xing;Xu Xuebin;Zhang Shaojie;Zheng Bingwu;Yang Xi;Wang Chaoqun;Li Ping;Ma Yuan;Li Kun;Chen Jie;Li Xiaohe;Shi Jun;Li Zhijun(School of Traditional Chinese Medicine,Beijing University of Chinese Medicine,Beijing 101000,China;Department of Anatomy,School of Basic Medical Sciences,Inner Mongolia Medical University,Hohhot 010110,Inner Mongolia Autonomous Region,China;Hohhot Zoo Management Office,Hohhot 010070,Inner Mongolia Autonomous Region,China;Department of Imaging,Inner Mongolia Medical University Affiliated Hospital,Hohhot 010050,Inner Mongolia Autonomous Region,China;Department of Function,The Second Affiliated Hospital of Inner Mongolia Medical University,Hohhot 010030,Inner Mongolia Autonomous Region,China;Center for Digital Medicine,School of Basic Medical Sciences,Inner Mongolia Medical University,Hohhot 010110,Inner Mongolia Autonomous Region,China;Department of Physiology,School of Basic Medical Sciences,Inner Mongolia Medical University,Hohhot 010110,Inner Mongolia Autonomous Region,China)

机构地区：[1]北京中医药大学中医学院,北京市101000 [2]内蒙古医科大学基础医学院解剖学教研室,内蒙古自治区呼和浩特市010110 [3]呼和浩特市动物园管理处,内蒙古自治区呼和浩特市010070 [4]内蒙古医科大学附属医院影像科,内蒙古自治区呼和浩特市010050 [5]内蒙古医科大学第二附属医院功能科,内蒙古自治区呼和浩特市010030 [6]内蒙古医科大学基础医学院数字医学中心,内蒙古自治区呼和浩特市010110 [7]内蒙古医科大学基础医学院生理学教研室,内蒙古自治区呼和浩特市010110

出　　处：《中国组织工程研究》2021年第35期5632-5637,共6页Chinese Journal of Tissue Engineering Research

基　　金：国家自然科学基金(81860382),项目负责人:王星;国家自然科学基金(81860383,81560348),项目负责人:李志军;国家自然科学基金(81660358),项目负责人:张少杰;内蒙古自然科学基金(2020MS03061),项目负责人:王星;内蒙古自然科学基金(2019MS08017),项目负责人:张少杰;内蒙古自然科学基金(2019MS08139),项目负责人:陈杰;内蒙古自治区科技发展计划项目(2019GG158),项目负责人:王星;内蒙古自治区科技发展计划项目(2019GG111),项目负责人:栗平;内蒙古医科大学科技百万项目(YKD2017KJBW009),项目负责人:王星;内蒙古医科大学科技百万项目(2015YKDKJBW03),项目负责人:张少杰;内蒙古医科大学青年创新基金(TKD2018QNCX071),项目负责人:王超群。

摘　　要：背景:猕猴与人类均属灵长类,其颈椎结构和生理功能及生存条件与人类十分相似,但目前对于猕猴全颈椎有限元分析的研究甚少。目的:建立成年猕猴C_(0)-T_(1)颈椎有限元模型及相关运动效能与人类颈椎的有限元模型之间进行对比研究,以发现其差异性。方法:选择7岁龄成年雄性猕猴1只,于2019年12月在内蒙古医科大学附属医院影像科行多层螺旋CT扫描,将其原始颈椎CT数据导入Mimics 21.0中初步建立三维模型,用Cero优化模型几何结构,得到其颈椎仿真三维模型。将装配模型导入Hypermesh行四面体网格化,划分颈椎各节段、椎间盘、韧带等组织网格;再利用Abaqus&ANSYS构建颈椎有限元模型,同时参考相关有限元模型文献进行有效性验证。结果与结论:①成功建立猕猴颈椎三维(包含C0-T1及6个椎间盘、相关韧带)有限元模型,共536215单元、461915节点,模型整体仿真度高,细小结构进行了较高精度还原,具备较高的生物仿真性;②将该模型活动度与人类颈椎模型相关文献比较:前后屈伸均较正常成人小(P<0.05)、左右侧弯C_(2-3)、C_(3-4)、C_(6-7)节段小于文献标准差范围(P<0.05),而轴向旋转与以往文献对比差异不大(P>0.05);③说明猕猴颈椎有限元模型的运动效能与人类颈椎有限元模型存在较大的差异性,可为猕猴颈椎造模研究提供理论依据。BACKGROUND:Both rhesus monkeys and humans belong to primates,and their cervical vertebra structure,physiological function and living conditions are very similar to those of human beings.However,there are few studies on the finite element analysis of the whole cervical vertebra of rhesus monkeys.OBJECTIVE:To establish the C_(0)-T_(1) finite element model of cervical vertebrae of adult rhesus monkeys and to make a comparative study between the finite element models of cervical vertebrae of adult rhesus monkeys and human cervical vertebrae in order to find out the difference.METHODS:A 7-year-old adult male rhesus monkey was selected and scanned by multi-slice spiral CT in the Imaging Department of the affiliated Hospital of Inner Mongolia Medical University in December 2019.The original CT data of cervical vertebrae were introduced into Mimics21.0 to establish a preliminary three-dimensional model,and the geometric structure of the model was optimized by Cero to get the simulation three-dimensional model of cervical vertebrae.The assembly model was imported into Hypermesh for tetrahedral gridding to divide the tissue grids of various segments,intervertebral discs and ligaments of cervical vertebrae.Then the finite element model of cervical vertebra was constructed by Abaqus&ANSYS,and the validity was verified by referring to the relevant finite element model literature.RESULTS AND CONCLUSION:The three-dimensional finite element model of cervical vertebra of rhesus monkey(including C0-T1 and six intervertebral discs and related ligaments)was successfully established,with a total of 536215 elements and 461915 nodes.The overall simulation of the model was high,and the fine structure was restored with high precision,resulting in a high biological simulation performance.Comparing the range of motion of this model with that of human cervical vertebra model,we found that the flexion and extension of this model were smaller than those of normal adults(P<0.05),and left and right lateral bending of C_(2-3),C_(3-4) and C_(6-7)

关 键 词：成年猕猴 全颈椎 有限元分析 数字模型 人类 

分 类 号：R459.9[医药卫生—治疗学] R318[医药卫生—临床医学]