Efficacy and safety of Hemoheal cream in patients with hemorrhoids:a randomized double-blind placebo controlled clinical trial  

作　　者：Mehdi Zobeiri Fatemeh Parvizi Roja Rahimi Fatemeh Heydarpour Hamid Reza Sheikhan Jafar Navabi Mohammad Hosein Farzaei 

机构地区：[1]Internal Medicine Department,Imam Reza Hospital,Kermanshah University of Medical Sciences,Kermanshah 6734667149,Iran [2]Pharmaceutical Sciences Research Center,Kermanshah University of Medical Sciences,Kermanshah 6734667149,Iran [3]Department of Traditional Pharmacy,School of Persian Medicine,Tehran University of Medical Sciences,Tehran 1113913661,Iran [4]Medical Biology Research Center,Health Technology Institute,Kermanshah University of Medical Sciences,Kermanshah 6734667149,Iran [5]Clinical Research Development Center,Imam Khomeini Hospital and Department of Internal Medicine,Kermanshah University of Medical Sciences,Kermanshah 6734667149,Iran [6]Medical Technology Research Center,Health Technology Institute,Kermanshah University of Medical Sciences,Kermanshah 6734667149,Iran

出　　处：《Journal of Traditional Chinese Medicine》2021年第2期301-307,共7页中医杂志（英文版）

基　　金：Supported by Kermanshah University of Medical Sciences(grant No.96455)。

摘　　要：OBJECTIVE:To evaluate the efficacy and safety of Hemoheal cream,an anti-hemorrhoid herbal preparation,(inspired by Persian medicine literatures in a double-blind,randomized placebo-controlled trial.METHODS:Hemoheal cream consists of aqueous extract of Allium ampeloprasum L.,Commiphora mukul(Hook.Ex Stocks)Engl and the oil of Sesamum indicum L.Fifty-two patients with symptomatic hemorrhoids were randomized to receive hemoheal cream or placebo for 3 weeks.The patients were evaluated before and after the intervention in terms of the severity of anal irritation,bleeding,anal itching,pain,defecation discomfort and swelling sense,and overall subjective improvement(%),as well as any reported adverse events.RESULTS:The results showed that after 3 weeks of treatment,distribution of anal irritation,bleeding,pain as well as swelling sense were significantly different(P<0.05),while the analysis showed no significant differences between two groups for anal itching and defecation discomfort(P>0.05).Furthermore,a significant difference was observed between the overall subjective improvement of Hemoheal cream and placebo groups(P=0.012).One patient in the treatment group complained of rashes on the application site.CONCLUSION:The present study showed a positive effect of Hemoheal cream in improving clinical signs and symptoms in patients with hemorrhoids.

关 键 词：HEMORRHOIDS ALLIUM COMMIPHORA Sesamum Medicine Iranain traditional Controlled clinical trial 

分 类 号：R285[医药卫生—中药学]