Mechanism underlying effect of Chaihu Shugan San(柴胡疏肝散)on major depressive disorder:a network pharmacology-based study  

作　　者：MU Jie ZHANG Shuang TANG Feifei LIU Shuling ZHANG Qianyi DU Qianlei WANG Xueqian WANG Qingguo CHENG Fafeng 

机构地区：[1]Clinical basic teaching and Research Office of Traditional Chinese Medicine,Chengdu University of Traditional Chinese Medicine,Wenjiang District,Chengdu 611137,China [2]Innovation Team of"Basic Research on Application of Classical Prescription",Teaching and Research Department of Clinical Foundation of Chinese Medicine,School of Basic Medical Sciences,Beijing University of Chinese Medicine,Beijing 100029,China

出　　处：《Journal of Traditional Chinese Medicine》2021年第2期338-348,共11页中医杂志（英文版）

基　　金：Supported by the General Program of National Natural Science Foundation of China(No.81774122);Young Teachers Project of Beijing University of Chinese Medicine(No.2017-JYB-JS-002),College Level Project of Beijing University of Chinese Medicine(No.2019-JYB-XS-002);Projects of Sichuan Administration of Traditional Chinese Medicine(No.2020JC0035);Xinglin Scholar Project of Chengdu University of Traditional Chinese Medicine(No.BSH2020016)。

摘　　要：OBJECTIVE:To investigate the mechanism underpinning the effect of Chaihu Shugan San(柴胡疏肝散,CHSGS)on major depressive disorder(MDD).METHODS:We searched the compound components of from seven herbal ingredients of CHSGS from TCMSP,SymMap,ETCM,NPASS databases,and the chemical structure of the compound from PubChem,and collected the compound targets from TCMSP and TargetNet databases,and MDD-related targets from DiseaseGene Network.We established protein-protein interaction in the STRING database.Through gene mapping,topology analysis and enrichment analysis,the core targets and pathways of CHSGS for MDD,and the involved biological processes(BP),cell components(CC),and molecular functions(MF)were predicted.RESULTS:We collected a total of 1135 CHSGS compounds.After screening by ADME standards and the five rules of Ribinski,we obtained 99 different chemical components with different chemical structures,and related targets of 183 different CHSGS compounds.In the DiseaseGene Network,a total of 740 relevant targets for MDD were collected.Through gene mapping and topological analysis,62 related targets of CHSGS for MDD,24 targets with topological Chinese herbal medicine were obtained.Through enrichment analysis,10 relevant pathways and 3 core pathways were obtained with the involvement of 127 BP,27 CC,and 43 MF.CONCLUSION:There are multiple targets and signaling pathways are involved in the action of CHSGS in the treatment of MDD.

关 键 词：Depressive disorder major PHARMACOLOGY Chaihu Shugan San 

分 类 号：R285[医药卫生—中药学]