糖尿病患者发生甲状腺结节的危险因素及与中医体质的相关性分析  

Risk factors of thyroid nodule in diabetic patients and the correlation with Traditional Chinese Medicine constitution

作　　者：何欢 彭艳文 刘颖 薛婧[3] 赵锡艳[1] 徐心瑶 李鸣镝[1] He Huan;Peng Yanwen;Liu Ying;Xue Jing;Zhao Xiyan;Xu Xinyao;Li Mingdi(Department of Endocrinology,Guang’anmen Hospital,China Academy of Chinese Medical Sciences,Beijing 100053,China;Department of Endocrinology,Tangshan Hospital of Traditional Chinese Medicine,Tangshan 063000,China;Department of Integration of Traditional Chinese and Western Medicine,Nankai Hospital,Tianjin 300100,China)

机构地区：[1]中国中医科学院广安门医院内分泌科,北京100053 [2]河北省唐山市中医院内分泌科,063000 [3]天津市南开医院中西医结合科,300100

出　　处：《国际中医中药杂志》2021年第4期329-334,共6页International Journal of Traditional Chinese Medicine

摘　　要：目的探讨糖尿病患者发生甲状腺结节的危险因素及与中医体质的关系。方法选择2019年1月-2020年8月中国中医科学院广安门医院内分泌科、唐山市中医院内分泌科糖尿病患者213例,进行症状及体质问卷调查,以是否合并甲状腺结节为判定标准分为糖尿病有甲状腺结节组(病例组)与糖尿病无甲状腺结节组(对照组),比较2组的临床特征,采用多因素logistic回归模型分析糖尿病患者合并甲状腺结节的危险因素及其与中医体质的关系。结果多因素logistic回归分析显示,年龄在50~80岁[OR=2.949,95%CI(1.266~6.714)]、女性[OR=3.736,95%CI(1.823~1.541)]、糖尿病病程≥15年[OR=1.558,95%CI(1.623~1.585)]、HbA1c异常升高[OR=5.862,95%CI(1.418~23.629)]、极低密度脂蛋白胆固醇(VLDL)异常升高[OR=2.851,95%CI(1.597~6.824)]、经常失眠[OR=1.970,95%CI(1.315~3.395)]、气郁质[OR=4.357,95%CI(2.634~8.377)]、血瘀质[OR=4.420,95%CI(1.874~15.258)]的糖尿病患者更易患甲状腺结节(P<0.05)。结论年龄为50~80岁、女性、糖尿病病程≥15年、HbA1c异常升高、VLDL异常升高、经常失眠、气郁质、血瘀质的糖尿病患者更易患甲状腺结节;气郁质、血瘀质为其危险体质。Objective To explore the risk factors of thyroid nodules in diabetic patients and its correlation with Traditional Chinese Medicine(TCM)constitution.Methods A Total of 213 cases of diabetic patients in Guang’anmen Hospital and Tangshan Hospital from January 2019 to August 2020 were choosen to do the questionnaire,with containly symptom and constitution.The patients were divided into diabetes with thyroid nodules group and diabetes without thyroid nodules group according to whether thyroid nodules were combined.We compared the clinical data characteristics of 2 groups,and used multi-factor logistic regression model to analyze the risk factors of diabetic patients with thyroid nodules and their correlation with TCM constitutions.Results Diabetes patients aged from 50-80 years old[OR=2.949,95%CI(1.266-6.714)],females[OR=3.736,95%CI(1.823-1.541)],diabetes duration≥15 years[OR=1.558,95%CI(1.623-1.585)],elevated HbA1c[OR=5.862,95%CI(1.418-23.629)],elevated VLDL[OR=2.851,95%CI(1.597-6.824)],frequent insomnia[OR=1.970,95%CI(1.315-3.395)],Qi stagnation[OR=4.357,95%CI(2.634-8.377)],blood stasis[OR=4.420,95%CI(1.874-15.258)]are more likely to suffer from thyroid nodules(P<0.05).Conclusion Diabetic patients aged from 50-80 years old,females,diabetes duration≥15 years,elevated HbA1c,family history of thyroid nodules,frequent insomnia,and mood swings are more likely to develop thyroid nodules;qi stagnation and blood stasis are dangerous constitutions for diabetic patients with thyroid nodules.

关 键 词：糖尿病 甲状腺结节 危险因素 中医体质 回归分析 

分 类 号：R259[医药卫生—中西医结合]