耐甲氧西林金黄色葡萄球菌杀白细胞素致病性研究进展  

Progress in pathogenicity of Panton-Valentine Leukocidin produced by methicillin-resistant Staphylococcus aureus

作　　者：李儒博 钱素云[1] Li Rubo;Qian Suyun(Pediatric Intensive Care Unit,National Center for Children′s Health,Beijing Children′s Hospital,Capital Medical University,Beijing 100045,China)

机构地区：[1]国家儿童医学中心,首都医科大学附属北京儿童医院重症医学科,100045

出　　处：《中华微生物学和免疫学杂志》2021年第4期313-317,共5页Chinese Journal of Microbiology and Immunology

基　　金：北京市自然科学基金(7172075)。

摘　　要：金黄色葡萄球菌(金葡菌)是常见人类致病菌之一。既往报道以杀白细胞素(Panton-Valentine Leukocidin,PVL)为代表的毒力蛋白为细菌侵袭人体后的重要致病因子。随研究不断深入,目前有学者认为pvl基因的存在对金葡菌致病力影响较小。本文旨在回顾并总结近年关于pvl特点、分子流行病学、致病性及争议之处的相关研究。Staphylococcus aureus(S.aureus)is one of the most common human pathogens.It has been reported that Panton-Valentine Leukocidin(PVL)as a representative of virulence proteins is an important pathogenic factor for S.aureus infection.However,with the deepening of research,some researchers consider that pvl gene has little effect on the pathogenicity of S.aureus.This article aimed to review and summarize the recent studies on the features,molecular epidemiological characteristics,pathogenicity and controversy of pvl gene.

关 键 词：金黄色葡萄球菌 杀白细胞素 争议 进展 

分 类 号：R446.5[医药卫生—诊断学]