超声引导下囊内注射聚桂醇硬化治疗甲状腺囊性结节有效性及安全性的meta分析  

Ultrasound-guided sclerotherapy with injection of sclerosing agent polidocanol for thyroid cystic nodules:a meta analysis of its effectiveness and safety

作　　者：李明月 林印胜 陈梅 李承志[1] 张艳[1] LI Mingyue;LIN Yinsheng;CHEN Mei;LI Chengzhi;ZHANG Yan(Department of Intervention and Vascular Surgery,Affiliated First Hospital of Jinan University,Guangzhou,Guangdong Province 510632,China)

机构地区：[1]暨南大学附属第一医院介入与血管外科,广州510632

出　　处：《介入放射学杂志》2021年第4期374-379,共6页Journal of Interventional Radiology

摘　　要：目的系统评价注射硬化剂聚桂醇(PPI)及无水乙醇(PEI)对甲状腺囊性结节的有效性及安全性。方法系统检索万方数据知识平台、中国生物医学文献数据库(CBM)、中国期刊全文数据库(CNKI)、Web of Science、the Cochrane Library、EmBase和PubMed上有关注射硬化剂PPI治疗甲状腺囊性结节的随机对照试验。文献检索时间为建库至今。筛选文献、提取数据及文献的偏倚风险评价至少2名研究者独立完成,结果采用Cochrane软件RevMan5.3软件进行分析。结果纳入7篇随机对照研究,共918例患者,PPI组468例,PEI组450例,PPI组与PEI组治疗甲状腺囊性结节在有效性上差别无统计学意义(OR=1.10,95%CI(0.69,1.86),P=0.36),PPI组治疗甲状腺囊性结节术后并发症发生率小于PEI组,差异有统计学意义(OR=0.25,95%CI(0.17,0.35),P=0.77),所有试验均未报道死亡。结论超声引导下囊内注射PPI硬化治疗甲状腺囊性结节的临床疗效与PEI相似,但在术后并发症发生率上小于PEI组。Objective To systematically evaluate the effectiveness and safety of sclerosing agents polidocanol(PPI)and absolute ethanol(PEI)in treating thyroid cystic nodules.Methods Computerized retrieval of randomized controlled trial(RCT)papers concerning injection of PPI for the treatment of thyroid cystic nodules from the databases of Wanfang Data Knowledge Platform,China Biomedical Database(CBM),Chinese Periodical Full-text Database(CNKI),Web of Science,the Cochrane Library,EmBase,and PubMed,which were published in the period from the database was established to this article was written,was conducted.The papers were screened,the data were extracted and the risk of bias in the literature was evaluated,which were done by at least two independent researchers.Meta analysis was performed by using Cochrane RevMan5.3 software.Results A total of 7 RCT papers including 918 patients were enrolled in this study.PPI group had 468 patients and PEI group had 450 patients.No statistically significant difference in clinical effectiveness existed between the two groups(OR=1.10,95%CI:0.69 and 1.86,P=0.36).The incidence of postoperative complications in PPI group was remarkably lower than that in PEI group,the difference was statistically significant(OR=0.25,95%CI:0.17 and 0.35,P=0.77).No death event was reported in all RCT papers.Conclusion In treating thyroid cystic nodules with ultrasound-guided injection of sclerosing agents,PPI and PEI have similar clinical efficacy,but the incidence of postoperative complications of PPI is lower than that of PEI.

关 键 词：甲状腺结节 聚桂醇 有效性 安全性 META分析 

分 类 号：R581.3[医药卫生—内分泌]