质子泵抑制药给药与不对称二甲基精氨酸相关性的临床探索性研究  

Clinical exploratory research on the correlation between the proton pump inhibitors administration and the asymmetric dimethylarginine

作　　者：刘雪梅 吴晓霏 贾冉冉 张繁 高慧桃 郎丽巍 田晔 欧宁[3] 胡海棠 江骥 王洪允 LIU Xue-mei;WU Xiao-fei;JIA Ran-ran;ZHANG Fan;GAO Hui-tao;LANG Li-wei;TIAN Ye;OU Ning;HU Hai-tang;JIANG Ji;WANG Hong-yun(Clinical Pharmacology Research Center,Peking Union Medical College Hospital,Peking Union Medical College and Chinese Academy of Medical Sciences,Beijing 100730,China;Department of Pharmacy,Peking University People’s Hospital,Beijing 100044,China;Research Department of Phase Ⅰ Clinical Trial,Jiangsu Province Hospital,Nanjing 210000,Jiangsu Province,China;Livzon Pharmaceutical Co.Ltd Zhuhai 519020,Guangdong Province,China)

机构地区：[1]中国医学科学院,北京协和医学院,北京协和医院,临床药理研究中心,北京100730 [2]北京大学人民医院药剂科,北京100044 [3]江苏省人民医院Ⅰ期临床研究室,江苏南京210000 [4]丽珠制药有限公司,广东珠海519020

出　　处：《中国临床药理学杂志》2021年第9期1044-1047,1051,共5页The Chinese Journal of Clinical Pharmacology

基　　金：国家科技重大专项基金资助项目(2019ZX09734001)。

摘　　要：目的探索质子泵抑制药(PPIs)药物暴露与不对称二甲基精氨酸(ADMA)体内水平动态变化之间的相关性。方法健康志愿者和十二指肠溃疡患者静脉输注艾普拉唑20 mg或埃索美拉唑40 mg,获取受试者的系列血浆样本并检测其中PPIs和ADMA浓度水平,以研究ADMA随PPIs给药的动态变化及两者之间的相互作用模式。结果健康志愿者(n=15)和十二指肠溃疡患者(n=20)的ADMA基线值分别为(0.44±0.05)和(0.53±0.09)μmol·L^(-1)。健康志愿者及患者血浆ADMA水平均未随PPIs浓度的改变发生显著波动,且两者不存在显著相关性(P>0.05)。结论 PPIs的使用并没有提高ADMA的水平,健康志愿者和患者的PPIs暴露与ADMA的水平之间均未展示出显著相关性。Objective To elucidate the relationship between proton pump inhibitors(PPIs) exposure and asymmetric dimethylarginine(ADMA) kinetic elevation. Methods Healthy volunteers and patients with duodenal ulcer received intravenous infusion of ilaprazole 20 mg or esomeprazole 40 mg, and a series of plasma samples were collected. Plasma levels of ADMA and PPIs were detected synchronously to investigate the interactional pattern between PPIs and ADMA. Results The ADMA baseline were(0.44±0.05) μmol·L^(-1) in healthy volunteers(n=15) and(0.53±0.09) μmol·L^(-1) in patients with duodenal ulcer(n=20), respectively. Plasma ADMA levels in healthy volunteers and patients did not fluctuate significantly after PPIs administration. Furthermore, the plasma levels of ADMA were not statistically correlated with PPIs exposure(P>0.05).Conclusion The PPIs administration did not elevate the ADMA levels and there was no demonstrated relationship between PPIs exposure and ADMA levels in both healthy volunteers and patients.

关 键 词：质子泵抑制药 心血管疾病风险 不对称二甲基精氨酸 一氧化氮 

分 类 号：R975.6[医药卫生—药品]