联合吸入LABA、ICS、LAMA对COPD患者肺功能的影响  

Study on the Lung Functional Effect with the Inhalations of LABA,ICS and LAMA in COPD Patients

作　　者：冼宏 叶永青 陈利霞 甘凤英 刘国栋 XIAN Hong;YE Yong-qing;CHEN Li-xia;GAN Feng-ying;LIU Guo-dong(Heyuan People's Hospital,Guangdong Heyuan 517000)

机构地区：[1]河源市人民医院,广东河源517000

出　　处：《深圳中西医结合杂志》2021年第5期143-144,共2页Shenzhen Journal of Integrated Traditional Chinese and Western Medicine

摘　　要：目的:探析联合吸入长效抗胆碱能药物(LAMA)、长效β2激动剂(LABA)、吸入性糖皮质激素(ICS)对慢性阻塞性肺疾病(COPD)患者肺功能的影响。方法:选取河源市人民医院2018年3月至2019年3月收治的96例COPD患者,以随机数字表法分组,对照组(48例)行常规治疗,观察组(48例)于对照组基础上加LABA、ICS、LAMA联合吸入治疗。随后比较两组患者的肺功能情况。结果:治疗前两组患者第1秒用力呼气容积(FEV1)、第1秒用力呼气量占用力肺活量比值(FEV1/FVC)比较,差异无统计学意义(P>0.05);治疗后观察组FEV1、FEV1/FVC均高于对照组,差异具有统计学意义(P<0.05)。结论:LABA、ICS、LAMA药物联合吸入,患者肺部功能有效得到改善,其生活质量明显提高。Objective To discuss the lung function with LAMA (long acting muscarinic antagonist),LABA (long acting β2 agonist) and ICS (inhaled corticosteroids) combined inhalations in chronic obstructive pulmonary disease (COPD) patients.Methods 96 COPD patients treated from March 2018 to March 2019 in Heyuan people’s hospital were selected and randomly assigned to observation group (48 cases) and control group (48 cases).The control group took the routine treatment;on the basis of the former,the observation group took the combined inhalation therapy of LABA,ICS and LAMA.Lung function were probed.Results Before treatment,there were no significant between-group differences of FEV1 (forced expiratory volume in one second) and FEV1/FVC (FEV1 to forced vital capacity ratio) (P > 0.05);after treatment,FEV1 and FEV1/FVC values in the observation group were higher than control group (P < 0.05).Conclusion The combined inhalation therapy of LABA,ICS and LAMA can effectively improve COPD patients’ lung function and increase the life quality.

关 键 词：慢性阻塞性肺疾病 吸入性糖皮质激素 长效抗胆碱能药物 长效Β2激动剂 

分 类 号：R563[医药卫生—呼吸系统]