疫情期间非COVID-19患者静脉血栓栓塞症临床特征的单中心研究  

A single center study on the clinical characteristics of venous thromboembolism in the patients without COVID-19 during the pandemic

作　　者：钱成 顾建平[1] 楼文胜[1] 陈国平[1] 汪涛 李英豪 Qian Cheng;Gu Jianping;Lou Wensheng;Chen Guoping;Wang Tao;Li Yinghao(Department of Interventional Radiology,Nanjing First Hospital,Nanjing Medical University,Nanjing 210006,China)

机构地区：[1]南京市第一医院介入血管科,南京210000

出　　处：《中华血管外科杂志》2021年第1期32-37,共6页Chinese Journal of Vascular Surgery

基　　金：南京医科大学科技发展基金一般项目(NMUB2019144)。

摘　　要：目的:探讨新型冠状病毒肺炎(COVID-19)疫情是否影响非COVID-19患者的静脉血栓栓塞症(VTE)临床特征。方法:回顾性分析疫情期间(2020-01-23至2020-04-16)南京市第一医院介入血管科收治的因VTE就诊的非COVID-19患者临床资料,与2019同期VTE患者资料进行对比分析;同时以3月15日(全国大部分城市确诊患者清零)作为节点,将疫情分为前后两期,观察分析疫情对非COVID-19患者VTE临床特征的影响。结果:本中心疫情期间共收治202例非COVID-19患者,其中VTE患者49例(24.3%);往年同期共收治273例患者,VTE患者54例(19.8%)。疫情期间以活动减少为主要诱因发生VTE的患者比例高于往年同期(49%比27.8%,P=0.027)。疫情前期就诊患者PE发生率高于疫情后期(72.7%比21.1%,P=0.002),且均累及双侧肺动脉。此外,疫情期间60~74岁的VTE患者占46.9%,较2019年同期(33.3%)有增加趋势。结论:疫情居家隔离期间,非COVID-19患者因活动减少而发生VTE的风险增加。疫情也影响了VTE就诊特征,前期症状性PE就诊比例增高。Objective To evaluate whether the pandemic affects the clinical characteristics of venous thromboembolism(VTE)in patients without COVID-19.Methods The clinical data of VTE patients without COVID-19 treated at the Department of Interventional Radiology of Nanjing First Hospital during the pandemic(2020-01-23 to 2020-04-16)were retrospectively analyzed and compared with that in the same period of 2019.The COVID-19 pandemic was divided into two phases with March 15th as a time node when most cities in China cleared all confirmed cases.The effect of the pandemic on VTE patients without COVID-19 was then observed and analyzed.Results During the pandemic,a total of 202 patients without COVID-19 were treated in our center,including 49 patients with VTE(24.3%).In the same period of 2019,a total of 273 patients were treated,including 54 patients with VTE(19.8%).The proportion of patients with VTE with reduced activity as the main trigger during the pandemic was significantly higher than that in the same period of 2019(49%vs 27.8%,P=0.027).The incidence of pulmonary embolism(PE)in the early stage of the pandemic was significantly higher than that in the later stage(72.7%vs 21.1%,P=0.002),and bilateral pulmonary arteries were involved in all the cases.During the pandemic,46.9%of VTE patients aged 60-74 years,demonstrating an increase compared with that in the same period of 2019(33.3%).Conclusions The pandemic increases the risk of patients without COVID-19 developing VTE due to reduced activity during home isolation.It also affects the characteristics of treatment of VTE with an increased proportion of medical visits driven by symptomatic PE in the early stage.

关 键 词：新型冠状病毒肺炎 静脉血栓栓塞症 深静脉血栓形成 肺栓塞 

分 类 号：R543.6[医药卫生—心血管疾病]