初级视皮层神经元非经典感受野研究的新进展  

The Research Progress of Non-classical Receptive Field in Primary Visual Cortex

作　　者：陈科 杨棹夕 廖柏涛 侯博钧 杨吟[3] 刘铁军[2] 夏阳[2] 尧德中[2] CHEN Ke;YANG Zhao-Xi;LIAO Bai-Tao;HOU Bo-Jun;YANG Yin;LIU Tie-Jun;XIA Yang;YAO De-Zhong(Sichuan Academy of Medical Sciences&Sichuan Provincial People's Hospital,Medical College,University of Electronic Science and Technology of China,Chengdu 610054,China;MOE Key Laboratory for NeuroInformation,School of Life Science and Technology,University of Electronic Science and Technology of China,Chengdu 610054,China;Department of Ophthalmology,Sichuan Academy of Medical Sciences&Sichuan Provincial People's Hospital,University of Electronic Science and Technology of China,Chengdu 610054,China)

机构地区：[1]电子科技大学医学院,四川省人民医院,成都610054 [2]电子科技大学生命科学与技术学院,神经信息教育部重点实验室,成都610054 [3]四川省人民医院眼科,成都610054

出　　处：《生物化学与生物物理进展》2021年第4期386-392,共7页Progress In Biochemistry and Biophysics

基　　金：国家自然科学基金(81771925,61933003,81861128001)资助项目。

摘　　要：感觉皮层神经元的非经典感受野(简称"外周")对经典感受野(简称"中心")的调节作用广泛存在于哺乳动物中,被认为是感觉皮层神经元的基本特性.以初级视皮层神经元为例,刺激其外周能有效地调节刺激其中心引起的反应,这种作用主要是抑制性的.理解初级视皮层神经元的外周对中心的调节机制能够深入揭示哺乳动物的感觉皮层神经元信息处理的基本原则.本文综述了引起初级视皮层神经元非经典感受野对经典感受野调节作用的神经环路机制和计算模型研究的进展.ensory cortex neurons of non-classical receptive field on the classical receptive field adjustment widely exist in mammals, is considered to be the basic characteristic of the sensory cortex neurons. In primary visual cortex of mammals, there was a larger non-classical receptive filed(n CRF) region beyond the classical receptive field(CRF). Although the region was not directly respond to the visual stimulus, it can modulate cell’s response in classical receptive fields. Understanding the modulatory mechanism of non-classical receptive field in V1 neurons can reveal the basic principles of information processing in mammalian sensory cortical neurons. At present, many studies found that modulatory mechanism of n CRF arises from feed forward, horizontal, and feedback interactions with local recurrent connections through synaptic mechanisms involved in increased inhibition and reduction of recurrent excitability. The modulatory by n CRF can effectively reduce the redundancy of the visual input. In general, surround suppression is generated by multiple connection types. Feedforward and horizontal connections in V1 mainly provide surround suppression from just outside the classical receptive field,and feedback from progressively higher areas provide modulation from progressively more distant surround regions. Moreover, feedback connections from different cortical areas likely modulate V1 responses in a stimulusspecific fashion, which is crucial for the large-scale information processing in the primary visual cortex.

关 键 词：感觉皮层 初级视皮层 外周抑制 神经机制 计算模型 稀疏编码 

分 类 号：Q424[生物学—神经生物学]